潮气末二氧化碳分压在心搏骤停大鼠复苏期的变化

The change of end-tidal carbon dioxide partial pressure(PetCO_2) in heart arrest rat during cardiopulmonary resuscitation

目的探讨潮气末二氧化碳分压(PetCO2)变化对大鼠心肺复苏(CPR)预后的影响。方法SD大鼠60只,气管插管机械通气,制作窒息8分钟心跳骤停模型,按照复苏结果分为失败组和成功组,观察PetCO2在心肺复苏(CPR)过程中的变化。结果(1)自主循环恢复的40例(成功组)PetCO2平均值(43.1mmHg)与自主循环未恢复的20例(失败组)PetCO2平均值(9.5mmHg)比较有高度显著性差异(P<0.01)。(2)失败组在窒息前后PetCO2比较差异有高度显著性(P<0.01)。(3)成功组与失败组在自主循环恢复前PetCO2比较差异无显著性(P>0.05)。结论CPR过程中PetCO2的监测对复苏预后有预测作用。

Objective To evaluate the change of rat end-tidal carbon dioxide on prognosis of cardiopuhlmonary resuscitation（CPR）. Methods Change of PetCO2 in 60 cardiac arrest rats induced by 8 minutes asphyxiation during CPR was observed. The rat were divided into 2 groups according to the result of standard external CPR. Results The average PetCO2 in 40 rats with the return of spontaneous circulaticn （ROSC） significandy higher than that in 20 rats without the ROSC（43.1mmHg VS 9.5mmHg P 〈 0.01 ）. （2）The average PetCO2 in failure cases had significandy difference between befere and after the ROSC （ P 〈 0.01 ） （3）The average PetCO2 before the ROSC had no sigrtificandy difference between successful cases and failure cases（ P 〉0.05）. Conclusion Monitoring PetCO2 during CPR has a predictive value on the success of resuscitation.