秋水仙碱在多壁碳纳米管修饰电极上的伏安行为及其应用

Voltammetric Behaviors of Colchicine and its Application at the Multi-Wall Carbon Nanotube Modified Electrode

制备多壁碳纳米管修饰电极，并研究秋水仙碱在该修饰电极上的伏安行为．发现多壁碳纳米管能显著提高秋水仙碱的氧化峰电流．通过选择和优化各项参数，建立了一种直接测定秋水仙碱的电分析方法．该方法的线性范围为2．0×10^-7～1.0×10^-5mol／L，开路富集2min后检出限为8．5×10^-8mol／L．5．0×10^-6mol／L秋水仙碱平行测定10次的相对标准偏差（RSD）为4．8％．并成功应用于秋水仙碱片剂中秋水仙碱的含量测定．

A multi - wall carbon nanotube （MWNT） film - coated glassy carbon electrode （GCE） was fabricated, and the voltammetric behavior of colchicine on the MWNT film - coated GCE was investigated. It is found that MWNT film significantly enhances the oxidation peak current of colchicine. All the experimental parameters were optimized and a sensitive electrochemical method was developed for the determination of colchicine. The oxidation peak current is proportional to the concentration of colchicine from 2.0×10^-7 to 1.0× 10^-5mol/L. The detection limit is about 8.5 ×10^-8 mol/L for 2 rain accumulation. Tile relative standard deviation（ n = 10） was 4.8% for 5.0× 10^-6mol/L colchicine. The proposed method was demonstrated by using colchicine table.