摘要
A combined genotype of polymorphisms of methionine metabolism has been associated with CNS demyelination in methotrexate-treated patients. Within a sample of 86 patients with X-linked adrenoleukodystrophy, this genotype was overrepresented in a subgroup of 15 patients with adrenomyeloneuropathy (AMN) with CNS demyelination (adrenoleukomyeloneuropathy) in comparison to 49 AMN patients without CNS demyelination (“pure”AMN; p = 0.002), suggesting that methionine metabolism might contribute to the phenotypic variability in adrenoleukodystrophy.
A combined genotype of polymorphisms of methionine metabolism has been associated with CNS demyelination in methotrexate-treated patients. Within a sample of 86 patients with X-linked adrenoleukodystrophy, this genotype was overrepresented in a subgroup of 15 patients with a- drenomyeloneuropathy （AMN） with CNS demyelination （adrenoleukomyeloneuropathy） in comparison to 49 AMN patients without CNS demyelination （＂pure＂ AMN; p = 0.002）, suggesting that methionine metabolism might contribute to the phenotypic variability in adrenoleukodystrophy.
出处
《世界核心医学期刊文摘（神经病学分册）》
2006年第9期9-10,共2页
Digest of the World Core Medical Journals:Clinical Neurology
