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血小板膜糖蛋白1bα基因Kozak序列-5T/C多态性与冠心病的关系 被引量：1

Association of Platelet Glycoprotein Ib α Kozak-5T/C Gene Polymorphism with the Susceptibility to Coronary Heart Disease
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摘要 目的探讨血小板膜糖蛋白Ibα(GPIbα)基因Kozak-5T/C多态性与冠心病及其病变程度的关系。方法应用聚合酶链反应—限制型片段长度多态性技术(PCR-RELP)检测196例浙江地区汉族人(冠心病组105例,对照组91例)Kozak-5T/C基因型及等位基因频率。结果GPIbα基因Kozak-5T/C多态性在冠心病组及对照组,单支病变组与多支病变组之间的分布差异没有显著性。结论GPIbα基因Kozak-5T/C多态性与冠心病的关系仍需进一步探讨。 Objective To explore the correlation between polymorphism of platelet glycoprotein Ibα Kozak-5T/C （GPlba） gene and suseeptihility to coronary heart disease as well as severity of coronary lesion. Methods One-hundred and five patients with angiographically confirmed coronary heart disease and nlnety-one controls were genotyped for the Kozak-5T/C polymorphism by polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） analysis. Results There was no statistical difference of genotype frequency or allele frequency of GPIbα gene, either between 105 patients and 91 controls, or between single-vessel lesions group and multi-vessel lesions group. Conclusion The relationship between polymorphism of GPIbα gene and coronary heart disease needs to be further discussed.
作者 阮宏标 徐耕 金重赢 金国栋
机构地区 浙江大学医学院附属第二医院
出处 《浙江预防医学》 2006年第10期8-10,共3页 Zhejiang Journal of Preventive Medicine
关键词 冠状动脉粥样硬化性心脏病 基因多态性 血小板膜糖蛋白Ibα(CPIbα) Coronary heart disease Polymorphism Platelet glycoprotein Ibα Kozak-5T/C gene
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献8

  • 1Corral J,Gonzalez-Conegero R,Lozano ML,et al.New alleles of the platelet glycoprotein Iba gene[J].BrHaematol,1998,103:997～1003.
  • 2H Douglas,K Michaelides,D A Gorog,et al.Platelet membrane glycoprotein lbα gene -5T/C Kozak sequence polymorphism as an independent risk factor for theoccurrence of coronary thrombosis[J].Heart,2002,87:70 ～ 74.
  • 3Afshar-Kharghan V,Li CQ,Khoshnevis-Asl M,et al.Kozak sequence polymorphism of the glycoprotein (GP) lb alpha gene is a major determinant of the plasma membrane levels of the platelet GP Ib-Ⅸ-Ⅴ complex.[J].Blood,1999:94 (1):1864～ 191.
  • 4Meisel C,Afshar-Kharghan,Casorbi I,et al.Role of Kozak sequence polymorphism of platelet glycoprotein Iba as a risk factor for coronary artery disease and catheter interventions[J].Am Coll Cardiol,2001;38:1023 ～ 1027.
  • 5Baker RI,Eikelboom J,Lofthouse E,et al.Platelet glycoprotein Iba Kozakpolymorphism is associated with an increased risk of ischemic stroke[J].Blood,2001; 98:36～40.
  • 6Afshar-kharghan V,Khoshvevis-Asl M,Hopkins P,et al.Polymorphism of the platelet glycoprotein (GP) Iba Kozak sequence determines the surface level of the GPIb-Ⅸ-Ⅴ complex and risk for early myocardial infarction[J].Blood,1998,92:702a.
  • 7Corral J,Lozano MI,Gonzalez-Conejero R,et al.A common polymorphism flanking the ATG initiator codon of GPIb alpha does not affect expression and is nota major risk factor for arterial thrombosis[J].Thromb Haemost,2000,83:23 ～ 28.
  • 8吕明恩,汪家敏,白霞,王兆钺,阮长耿.脑梗死患者血小板糖蛋白Ibα kozak序列多态性研究[J].江苏医药,2003,29(10):781-782. 被引量：6

二级参考文献6

  • 1Afshar-Kharghan V, Li C, Khoshnevis-Asl M, et al. Kozak sequence polymorphism of the glycoprotein(GP)Ibα gene is a major determinant of the plasma membrane levels of the platelet GPIb-IX-V complex.Blood,1999,94:186-191.
  • 2Mikkelsson J,Perola M,Penttila A,et al.Platelet glycoprotein Ibalpha HPA-2 Met/VNTR B haplotype as a genetic predictor of myocardial infarction and suddern cardiac death.Circulation,2001,104:876-880.
  • 3Santoso S,Zimmerman P,Sachs UJH,et al.The kozak sequence polymorphism of the plycoprotein Ibα gene is associated with the extent of coronary artery disease in younger patients.Blood,2000,96(Suppl):624a.
  • 4Afshar-Kharghan V,Khoshnevis-Asl M,Hopkind P,et al.Polymorphism of the platelet glycopritein(GP)Ibα Kozak sequence determines the surface level of the GPIb-IX-V complex and risk for early myocardial infarction.Blood,1998,92(suppl 1):702a.
  • 5Baker RI,Eikelboom J,Lofthouse E,et al.Platelet glycoprolein Ibα kozak polymorphism is associated with an increased risk of ischemic stroke.Blood,2001,98:36-40.
  • 6施菊妹,高维强,白霞,阮长耿.苏州地区汉族人GPIbα基因启动子上游“Kozak”多态性研究[J].江苏医药,2002,28(10):738-740. 被引量：2

共引文献5

同被引文献8

  • 1吕明恩,汪家敏,白霞,王兆钺,阮长耿.脑梗死患者血小板糖蛋白Ibα kozak序列多态性研究[J].江苏医药,2003,29(10):781-782. 被引量：6
  • 2Corral J,Gonzalez-Conegero R,Lozano ML,et al.New alleles of the platelet glycoprotein I bagene[J].Br J Haema-tol,1998,103:997-1003.
  • 3Afshar-kharghan V,Khoshvevis-Asl M,Hopkins P,et al.Polymorphism of the platelet glycoprotein(GP) I baKozak sequence determines the surface level of the GP Ⅰb-Ⅸ-Ⅴ complex and risk for early myocardial infarction[J].Blood,1998,92:702a.
  • 4HDouglas,K Michaelides,DA Gorog,et al.Platelet membrane glycoprotein I bagene-5T/C Kozak sequence polymorphism as anindependent risk factor for the occurrence of coronary thrombosis[J].Heart,2002,87:70-74.
  • 5Corral J,Lozano MI,Gonzalez-Conejero R,et al.A common polymorphism flanking the ATG initiator codon of GP I b alpha does not affect expression and is not a major risk factor for arterial thrombosis[J].Thromb Haemost,2000,83:23-28.
  • 6Afshar-Kharghan V,Lu CQ,Khoshnevis-Asl M,et al.Kozak sequence polymorphism of the glycoprotein(GP) Ⅰb alpha sene is a major determinant of the plasma membrane levels of the platelet C,P Ⅰ b-Ⅸ-Ⅴ complex[J].Blood,1999,94(1):186-191.
  • 7Meisel C,Afshar-Kharghan,Casorbi I,et al.Role of Kozak sequence poiymorphism d platelet glycoprotein Ⅰ baas a risk factor for coronaryartery disease and catheter interventions[J].Am Coil Cardiol,2001,38:1023-1027.
  • 8Baker RI,Eikelboom J,Lofthouse E,et al.Pletelet glycoprotein IbaKozak polymorphism is associated with an increased risk of ischemicstroke[J].Blood,2001,98:36-40.

引证文献1

浙江预防医学
2006年 第10期

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