摘要
目的研究二氧化氯消毒液的致畸性和亚急性毒性。方法设0.1、0.3和1.0g/kg体重三剂量组,进行致畸研究;设0.04、0.2和1.0g/kg体重三个剂量组,进行亚急性毒性试验,观察二氧化氯消毒液对妊娠大鼠的致畸胎性和对大鼠的蓄积毒性作用。结果三个剂量组各项指标均未见有明显的母体毒性和胚胎毒性、致畸性和亚急性毒性。结论在本实验条件下,二氧化氯消毒液无致畸性和亚急性毒性。
Objective To study the teratogenicity and subacute toxicity of chlorine dioxide for its safety assessment. Methods A traditional teratogenic assay was carried out by setting 3 different dose groups with 0.1, 0.3 and 1.0g/kg. b. w in SD rats. A subaeute toxic study was conducted by setting another 3 different dose groups with 0.04, 0.2 and 1.0g/kg. b. w in SD rats. Result Teratogenicity, maternal toxicity and subacute toxicity could not be observed in any of the dose groups. Conclusion The study shows that chlorine dioxide has not teratogenic or subacute toxic potential for SD rats.
出处
《浙江预防医学》
2006年第10期13-14,共2页
Zhejiang Journal of Preventive Medicine
关键词
二氧化氯
致畸性
亚急性毒性
Chlorine dioxide disinfectant
Teratogenicity
Subacute toxicity
