老年患者鲍氏不动杆菌感染的分布及耐药性

Distribution and Antimicrobial Resistance of Acinetobacter baumannii Infection in Elderly Patients

目的 探讨老年患者鲍氏不动杆菌感染的分布特征及耐药性。方法 对我院2001年6月～2005年4月老年患者感染的鲍氏不动杆菌分布部位、患者基础疾病及其对15种抗菌药物的药敏结果进行分析。结果 检出184株鲍氏不动杆菌，标本来源为痰液、尿液、咽拭子、脓液等；对第三代头孢菌素和环丙沙星、氧氟沙星的耐药率均＞50．0％；耐药率最低的药物是亚胺培南，为2．2％，其次为阿米卡星（37．5％）和氨苄西林／舒巴坦（39．7％），耐药率最高的药物是氨苄西林，为83．2％。结论 老年患者感染的鲍氏不动杆菌耐药率较高，宜根据药敏试验结果合理选择抗菌药物。

OBJECTIVE To investigate the distribution and antimicrobial resistance of Acinetobacter baumannii infection in the elderly patients in our hospital. METHODS One hundred and eighty-four strains of A. baumannii isolated from elderly patients with infection from Jun 2001 to Apr 2005 were collected and antimicrobial susceptibility test was performed. RESULTS All strains of A. baurnannii were from sputum, urine, pus, etcl the resistance of the strains to the third generation cephalosporin, ciprofloxacin and ofloxacin was all more than 50.0% the resistance rate to imipenem was the lowest（2.2%）, followed by amikacin（37. 5 %）and ampicillin/ sulbactam （39. 7%）, and the resistant rate to ampicillin was the highest （83.2%）. CONCLUSIONS The antimicrobial resistance of A. baumannii in the elderly patients is high, the antibiotic treatment must depend on antimicrobial susceptibility test.