奥西康注射液在预防术后辅助化疗中恶心呕吐的临床应用

Clinical application of Aoxikang Injection to the prevention of nausea and vomiting induced by supportive post-operation chemotherapy

目的探讨奥西康注射液在食管癌术后辅助化疗中预防恶心、呕吐的临床应用价值。方法90例接受顺铂联合方案化疗的患者,随机分成对照组和治疗组,分别给予恩丹西酮和奥西康注射液联合恩丹西酮治疗,以控制辅助化疗中恶心、呕吐的发生。结果治疗组控制恶心、呕吐显效率及总有效率均高于对照组(P<0.05),平均呕吐次数少于对照组(P<0.05)。结论应用奥西康注射液联合恩丹西酮,可以显著地减少食管癌术后辅助化疗中恶心、呕吐的发生率。

Objective： To study the clinical effect of Aoxikang Injection on the prevention of nausea and vomiting induced by supportive chemotherapy after operation of esophageal carcinoma. Methods： Ninety patients under cispliatin-based chemotherapy were randomly divided into the control group （46cases） and the treatment group （44cases）, which were treated respectively with Ondansetron and Aoxikang Injection combined with Ondansetron to control nausea and vomiting induced by supportive chemotherapy. Results： There were significant differences between the two groups. The complete response rate and the total effective rate in the treatment group were all higher than these in the control group （P 〈0.05）. The average frequency of vomiting in the treatment group was also low er than that in the control group （P 〈0.05）. Conclusion： Aoxikang Injection combined with Ondansetron can prominently decrease the incidence of nausea and vomiting induced by supportive chemotherapy.