血管瘤和血管畸形MRI、MRA与VEGF表达的联系

Relationship between MRI and MRA features and vascular endothelial growth factor expression of peripheral hemangiomas and vascular malformations

目的：探讨周围软组织血管瘤和血管畸形MRI，MRA与VEGF表达的关系。方法：对71例血管瘤和血管畸形MRI，MRA表现与VEGF表达进行对照。结果：38例血管瘤，31例T2WI呈较高信号，7例呈高信号；7例VEGF表达（-），31例（＋～＋＋＋）。33例血管畸形，3例T2WI呈较高信号，30例呈高信号；31例VEGF表达（-），2例（＋）。血管瘤T2WI信号表现与VEGF表达密切相关。结论：血管瘤和血管畸形VEGF表达、MRI、MRA表现均不相同，MRI、MRA表现一定程度反应血管内皮增生程度与VEGF表达。

Objective To study the relationship between MRI and MRA features and vascular endothelial growth factor expression of peripheral hemangiomas and vascular malformations. Methods MRI and MRA features were compared with vascular endothelial growth factor expression in 71 patients with peripheral hemangiomas and vascular malformations. Results In 38 cases of peripheral hemangiomas, 31 cases showed increased signals and 7 cases showed markedly increased signals on T2-weighted images ; 31 cases were higher and 7 cases were lower in vascular endothelial growth factor expression in hemangiomas. In 33 cases of peripheral vascular malformations, 3 cases showed increased signals and 30 cases showed markedly increased signals on T2 weighted images; 2 eases were higher and 31 cases were lower in expression of vascular endothelial growth factor in vascular malformations. Vascular endothelial growth factor expression was closely related to the features of signals on T2-weighted images in hemangiomas. Conclusion Vascular endothelial growth factor expression, MRI, MRA features are different in peripheral hemangiomas and vascular malformations. MRI and MRA features can evaluate the degree of vascular endothelial ceil proliferation and vascular endothelial growth factor expression in hemangiomas.