低氧条件下耐力运动对大鼠血脂代谢的影响

Effect of Hypoxic Exercise to Blood Lipid Metabolism in Rat

实验选取雄性SD健康大鼠40只,随机分为4组,即常氧安静组、常氧运动组、低氧安静组、低氧运动组。常氧运动组每天在常氧动物跑台上以25 m/min、60 min/d、6 d/w运动;低氧运动组每天在相当于海拔2 500 m低氧动物跑台上以20 m/min、60 min/d、6 d/w运动,其余时间在低氧环境下居住。实验4 w之后采样测试指标,低氧运动组与常氧运动组比较,血甘油三酯浓度、血浆总胆固醇、低密度脂蛋白胆固醇下降幅度和高密度脂蛋白上升幅度、血清脂蛋白脂肪酶和骨骼肌脂蛋白脂肪酶的活性提高都更明显,提示低氧运动改善血脂代谢状态比常氧运动更为有效,更有利于外周组织胆固醇的清除,对防治动脉粥样硬化也更为有效。

40 male SD rats were randomly divided into 4 groups as following： Normoxie Control group, Normoxic exercise group, Hypoxic control group, Hypoxic exercise group. Normoxic exercise group was trained at treadmill 25 m/rain, 60 min/d, 6 d/w. Hypoxic exercise group was trained at 20 m/min, 60 min/d, 6 d/w in hypoxic chamber. After 4 weeks experiment , triglyceride （TG）, total cholesterol （TC） and LDL- cholesterol （LDL- C） decreased much, HDL- cholesterol （HDL- C） increased and lipoprotein lipase activity （ LPLA ） enhanced much higher in Hypoxic exercise group than Normoxic exercise group, All these suggest that Hypoxic exercise is better than normoxic exercise in improving blood lipid metabolism and eliminating cholesterol and it is a better way to prevent atherosclerosis.