血压变异性与靶器官损害初探

Preliminary inquiry on relationship between blood pressure variability and target-organ damage

对103例高血压病患者按临床分期行动态血压(ABP)监测,部分行左心室肌重量(LVM)测量,结果显示Ⅱ期组24h收缩压、Ⅲ期组的收缩压及舒张压变异性均明显大于Ⅰ期组(P<0.05),日间收缩压的变异性与24h收缩压相一致,夜间的舒张压变异性Ⅱ、Ⅲ期组亦明显大于Ⅰ期组(P<0.05),左心室肥厚(LVH)的检出率分别为Ⅰ期组20%、Ⅱ期组50%、Ⅲ期组70%.随着靶器官损害加重,血压变异性亦增大,故应用ABP监测高血压病患者的血压变异性可能对靶器官的损害程度具有预后价值.

Ambulatory blood pressure monitor (ABPM) was done on 103 hypertensive patients according to clinical stages and left ventricular measure (LVM) was randomly done on a portion of the patients. The results showed that the variability of stage-Ⅱ-group's 24 hour systolic pressure and stage-Ⅲ-group's systolic and diastolic pressures was significantly higher than that of stage-Ⅰ-group (P<0. 05). The systolic pressure during the day was in keeping with 24 hour systolic pressure;at night the diastolic pressure variability of stage-Ⅱ-group and stage-Ⅲ-group also was significantly higher than that of stage-Ⅰ-group (P<0. 05). The detectable rates of left ventricular hypertrophy en stage-Ⅰ-group,stage-Ⅱ-group and stage-Ⅲ-group were 20%, 50% and 70% respectively. As the target-organ damage was aggravated, the blood pressure variability was increased. Therefore, detecting the blood pressure variability of hypertensive patients by ABPM could be of prognotic value in estimating the degree of target-organ damage.