摘要
[A Review] LXRs,LXRα and LXRβ are ligand-activated transcription factors that are members of the nuclear receptor superfamily.LXRs preferentially bind with their heterodimeric partner,retinoid X receptor(RXR),to LXR response elements to activate gene expression.Cellular and whole-body cholesterol homeostasis is maintained through a network of transcriptional programs.Liver X receptors regulate key aspects of cellular and whole-body sterol homeostasis,including cholesterol absorption,lipoprotein synthesis and remodeling,lipoprotein uptake by peripheral tissues,reverse cholesterol transport,and bile acid synthesis and absorption.This review focuses on the role of liver X receptors in the control of cholesterol homeostasis.
LXRs, LXRα and LXRβ are ligand - activated transcription factors that are members of the nuclear receptor superfamily. LXRs preferentially bind with their heterodimeric partner, retinoid X receptor （RXR）, to LXR response elements to activate gene expression. Cellular and whole - body cholesterol homeostasis is maintained through a network of transcriptional programs. Liver X receptors regulate key aspects of cellular and whole - body sterol homeostasis, including cholesterol absorption, lipoprotein synthesis and remodeling, lipoprotein uptake by peripheral tissues, reverse cholesterol transport, and bile acid synthesis and absorption. This review focuses on the role of liver X receptors in the control of cholesterol homeostasis.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2006年第9期1854-1857,共4页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No.30470720)
关键词
受体
肝X
ATP结合匣式转运子
胆固醇
核受体
Receptors, liver X
ATP - binding cassette transporters
Cholesterol
Nuclear receptors
