血钠尿肽前体N末端在心力衰竭时的变化

Changes of blood N-terminal fragment of brain natriuretic peptide prohormone in patients with chronic heart failure

目的：观察慢性心力衰竭患者血B型钠尿肽前体N末端（NT-proBNP）的变化。方法：应用电化学发光法检测89例收缩性心力衰竭（收缩性心力衰竭组）和17例单纯舒张功能不全性心力衰竭患者（DHF组）以及22例心功能正常的对照组的血NT—proBNP水平。结果：收缩性心力衰竭组不同心功能级别患者的NT-proB—NP均显著高于对照组，且自Ⅰ～Ⅳ级心功能的NT—proBNP逐级升高，分别为（388．9±304．7）、（772．7±648．4）、（1946．4±1914．4）和（3743．4±2592．5）ng／L，DHF组为（578．1±848．3）ng／L，对照组为（69．5±51．2）ng／L。结论：血NT—proBNP的检测有助于对慢性心力衰竭的诊断。

Objective： To observe changes of blood NT proBNP （the N-terminal fragment of brain natriuretic peptide prohormone） levels in chronic heart failure. Method：Serum NT-proBNP were measured in 89 cases with systolic heart failure and 17 cases with diastolic heart failure with electrochemiluminescence immunoassay. Result： Serum NT-proBNP levels in patients with different NYHA classification were all higher than those in control group, showing a gradually increased pattern from Ⅰ to Ⅳ class （[388.9±304.7],[772.7±648.4],[1946.4±1 914.4] and [3743.4±2592.5]ng/L for NYHA Ⅰ -Ⅳ, and [69. 5±51. 2]ng/L for control group,respectively）. NT-proBNP also increased in patients with diastolic heart failure [ 578. 1 ± 848.3] ng/L. Conclusion： Serum NT- proBNP levels increases in systolic and diastolic heart failure. This increase can be used to help the diagnosis of heart failure.