摘要
客观：为了评估修理兔子的效果，快速的原型技术准备的光线的缺点 withpolyester/tricalcium 磷酸盐脚手架与牛的骨头装载了形态基因的蛋白质(bBMP ) ，并且为生长因素发现新搬运人。方法: 有或没有牛的 BMP 装载的快速的原型技术准备的 Polyester/tricalcium 磷酸盐脚手架被用来修理 15 公里在兔子的光线的缺点。然后 X 光线照相术的结果，组织学，脚手架降级率和骨头矿物质密度(BMD ) 被估价在第 12 星期检验效果。结果：在第 12 星期手术后地，与 bBMP 对待的所有缺点是图形地修理的无线电。没有 X 光线照相术的显示出的 bBMP 和组织学的联合，没有半径植入 polyester/tricalcium 磷酸盐脚手架。在试验性的组，薄片状的结构的纵的排列在第 12 星期组织学地被观察，显示改革骨头改变在不同的度是完全的。三个试验性的组，多骨的新生并且在 polylactide-co-glycolide/tricalcium 胼胝改变磷酸盐(PLGA/TCP ) 组最好。当 PLGA/TCP 脚手架组最高级时， BMD 价值是在第 12 星期的正常价值的 beyond70% ，并且没有畸形在包围被观察在所有组的软织物。结论: 与 bovineBMP 装载的快速的原型技术准备的 Polyester/tricalcium 磷酸盐脚手架能修理 15 公里兔子的光线的缺点。至于结果， PLGA/TCP 支架是比好的想法土地 poly L 乳的酸(PLLA/TCP ) 不是的 L-lactide-co-D， L 减水乳酸(PDLLA/TCP ) 支架，而是计策对它的低降级率那么好。
Objective： To evaluate the effects of repairing rabbit radial defects with polyester/tricalcium phosphate scaffolds prepared by rapid prototyping technology loaded with bovine bone morphogenetic protein （ bBMP）, and find new carriers for growth factors. Methods： Polyester/tricalcium phosphate scaffolds prepared by rapid prototyping technology loaded with and without bovine BMP were used to repair the 15 mm radial defect in rabbit. Then the results of radiography, histology, scaffolds degrade rates and bone mineral density （BMD） were appraised to examine the effects at the 12th week. Results ： At the 12th week postoperatively, all defects treated with bBMP were radiographically repaired. No radius implanted polyester/tricalcium phosphate scaffolds without bBMP showed radiographic and histological union. At experimental groups, longitudinal alignment of lamellar structure was observed histologically at the 12th week,indicating that remodeling of regenerated bone was complete in different degree. Of the three experimental groups, the bony regeneration and remodeling of callus in poly lactide-co-glycolide/tricalcium phosphate （PLGA/ TCP） group was the best. The BMD values were beyond 70% of normal value at the 12th week while the PLGA/ TCP scaffolds group was the highest, and no abnormalities were observed in the surrounding soft tissue in all groups. Conclusions - Polyester/tricalcium phosphate scaffolds prepared by rapid prototyping technology loaded with bovine BMP can repair a 15 mm radial defect of rabbit. As for the results, the PLGA/TCP scaffold is ideal and better than poly L-lactide-co-D, L-lactide （ PDLLA/TCP ） scaffold, but the ploy L-lactic acid （PLLA/TCP） is not so good for its low degradation rates.
