摘要
区别，房间的逐步的专门化， andtransdifferentiation，一种房间类型的明显的切换进另外一个，捕获许多干细胞聚光灯。但是 dedifferentiation，在它前的一个房间的发展颠倒重新发明自己，也是一个重要过程。在多细胞的有机体，细胞的 dedifferentiation 是位于新干细胞系的 totipotency，新生和形成下面的主要过程。Inhumans， dedifferentiation 经常与 carcinogenesis 被联系。在动物的 cellulardedifferentiation 的学习，与细胞命运开关和决心有关的特别地早的事件，被一个合适的、方便试验性的系统的缺乏限制。dedifferentiation 的经典例子是在 urodele 两栖动物的手足和尾巴新生，例如蝾螈。最近，当与适当信号或材料刺激了时，几个调查者证明了某些哺乳动物的房间打罐头嬉痞的集会 duced 到 dedifferentiate 到祖先房间。这些发现打开研究人员们可能由在 vivo 导致细胞的 dedifferentiation 提高哺乳动物的内长的再生能力的可能性。
Differentiation, the stepwise specialization of cells, and transdifferentiation, the apparent switching of one cell type into another, capture much of the stem cell spotlight. But dedifferentiation, the developmental reversal of a cell before it reinvents itself, is an important process too. In multicellular organisms, cellular dedifferentiation is the major process underlying totipotency, regeneration and formation of new stem cell lineages. In humans, dedifferentiation is often associated with carcinogenesis. The study of cellular dedifferentiation in animals, particularly early events related to cell fate-switch and determination, is limited by the lack of a suitable,convenient experimental system. The classic example of dedifferentiation is limb and tail regeneration in urodele amphibians, such as salamanders. Recently, several investigators have shown that certain mammalian cell types can be induced to dedifferentiate to progenitor cells when stimulated with the appropriate signals or materials. These discoveries open the possibility that researchers might enhance the endogenous regenerative capacity of mammals by inducing cellular dedifferentiation in vivo.
