依达拉奉对急性重型颅脑损伤疗效的临床观察

The therapeutic efficacy of edaravone in treatment of acute severe head injury

目的探讨依达拉奉注射液对急性重型颅脑损伤昏迷患者促醒作用以及对预后的影响。方法将60例重型颅脑损伤患者(GCS≤8分)随机分成两组。观察组30例在常规治疗的基础上加用依达拉奉促醒治疗,对照组30例采用常规治疗。两组于伤后6个月按GOS预后评分评定预后,同时比较两组患者的意识好转率。结果观察组恢复良好率(18/30)与对照组(8/30)比较差异有显著性意义(P＜0．05)观察组治疗后1个月清醒24例,而对照组14例,两组清醒率比较差异有显著性意义(P＜0．01)。两组清醒时间比较,观察组为(12．46±6．29)d,对照组为(15．95±7．53)d。结论依达拉奉治疗重型颅脑损伤昏迷患者时不仅能加速清醒,还能促进预后,提高生活质量。

Objective To investigate the therapeutic effect ofedaravone on the promoting reVival from coma and prognosis after acute severe head injury. Methods 60 patients with acute severe head injury （GSC ≤8） were randomly divided into two groups： edaravone group （n=30） treated with edaravone besides the routine treatment and control group （n=30） treated only with the conventional therapy. The clinical prognosis of the patients was evaluated between the two groups after six months since being injured according to GOS scores and the consciousness-improved rate, Results The rate of good recovery was 18/30 in the edaravone group, significantly higher than 8/30 of the control group （P〈0.05）. The consciousness of 24 cases after one month in the edaravone group was significantly improved but only 14 cases in control group （P〈0.01）. The revival time （12.46±6.29） in edaravone group was significantly shorter than that （15.95±7.53） in control group. Conclusion Edaravone can promote revival from coma and improve life quality among patients with acute severe head injury.