健脾益肾方对小鼠移植性前胃癌术后复发转移及生存期的影响

Effects of Jianpi Yishen Recipe on recurrence, metastasis and life span of mice transplanted with proventriculus squamous carcinoma after tumorectomy

目的:观察健脾益肾方对615小鼠移植性前胃癌术后肿瘤局部复发和肺转移的治疗作用及对生存期的影响。方法:以615小鼠前胃癌术后肺转移模型为对象,应用健脾益肾方治疗,并与5-FU化疗组和模型组进行对比,观察术后肺转移和局部复发及生存期。结果:模型组肺转移率为94.4%,复发率为94.44%,健脾益肾方治疗组肺转移率为68.4%,转移抑制率为27.5%,复发率为78.95%,复发瘤抑制率为65.35%;健脾益肾方治疗组荷瘤小鼠术后平均生存期及中位生存期明显延长,生命延长率为100%。结论:健脾益肾方对小鼠移植性前胃癌术后局部肿瘤复发及远处肺转移有一定的抑制作用,并延长生存期。

Objective： To observe the effects of Jianpi Yishen Recipe （JPYSR）, a compound Chinese herbal medicine, on recurrence, metastasis and life span of mice transplanted with proventriculus squamous carcinoma cells after tumorectomy. Methods： JPYSR was orally administered to 615 mice transplanted with proventriculus squamous carcinoma cells in the palma of left hind limb after tumorectomy. The local tumor recurrence, lung metastasis and life span of the mice were evaluated and compared with those of the 5-FU-treated mice and untreated mice. Results. The pulmonary metastasis rate was 94.4 % and the recurrence rate was 94.44 % in untreated group. The pulmonary metastasis rate was 68.4%, the inhibition rate of pulmonary metastasis was 27.5%, the recurrence rate was 78.95%, and the inhibition rate of tumor recurrence was 65.35% in JPYSR-treated group. The average and median life spans were obviously prolonged in JPYSR-treated group, as compared with those in untreated group. The life-prolonging rate was 100%. Conclusion： JPYSR can effectively inhibit the local recurrence and pulmonary metastasis of the transplanted proventriculus squamous carcinoma in mice after tumorectomy, and prolong the life span.