间苯三酚用量对分娩过程影响初探

Preliminary Study on Childbirth Course with Different Dose of Phloroglucinol

目的:观察不同剂量间苯三酚对促进产程进展的作用效果。方法:选择正常初孕妇66例,按间苯三酚不同用量随机分为40 mg(24例),80 mg(22例)和160 mg(20例)3组,观察3组孕妇产程变化及胎儿情况。结果:①活跃期,3组间两两比较,差异有显著性(P<0.05)。②第一产程时间,160 mg组与80 mg组比较差异无显著性(P>0.05),40 mg组与另两组比较差异有非常显著性(P<0.01)。③3组间产后出血量、新生儿Apgar评分差异无显著性(P>0.05)。结论:间苯三酚可有效加速产程进展,且与剂量有较密切相关性,使用160 mg间苯三酚静脉推注效果最为明显,且对母儿无明显的不良影响,为临床加速产程进展提供了一种治疗选择。

Objective： To observe the effects of different dose of Phloroglucinol on childbearing course. Methods： Sixty-six pregnant women were randomly divided into three groups according to Phloroglucinol dosage： 160 mg group （ n = 20）. 80 mg group （ n = 22）. and 40 rng group （ n = 24）. The labor time. fetal distress. and postpartum hemorrhage were evaluated in three groups. Results：①The mean time of active phase was 53.25±13.31 min,82.73 ±47.23 min, and 120.63 ± 43.52 min in 160 mg group, 80 mg group and 40 mg group, respectively. There were significant difference among the three groups （ P〈0.01 ） ②The total time of first stage of labor were 382.25±146.63 min, 358.64 ± 176.09 min, and 603.75 ±218.41 min in 160 mg group, 80 mg group, and 40 mg group, respectively, There was no significant difference between the former two groups （ P〉0.05） ,but differed from 40 mg group （ P〈 0.01）. ③There were no significant difference in the fetal suffocation. newbom weight. and amount of postpartum hemorrhage among the three groups. Conclusions： Phloroglucinol can effectively improve labor progress and its dose is positive correlation with shorten active phase of labor.To obtain predominant effect.160 mg Phloroglucinol is preferred by intravenous injection.