心脏特异性高度表达的抗凋亡蛋白——ARC

An Anti-apoptotic Protein Expressed Specifically and Highly in The Cardiac Tissue:ARC

与凋亡(apoptosis)相关的许多心脏疾病如心肌梗死、心肌病及心衰等严重威胁着人类的健康和生命.寻找有效手段防治这些心脏病是当前医学研究的热点.ARC(带有caspase富集功能域的凋亡抑制因子)是新近发现的唯一在心脏大量且特异表达的抗凋亡蛋白,其全称是带有caspase富集功能域的凋亡抑制因子.ARC可被持续性磷酸化并参与阻断凋亡发生途径的多个层面.因此,ARC是一种强大的抗心肌凋亡蛋白.

Many apoptosis-related heart diseases such as myocardial infarction, cardiomyopathies, and heart failure severely impair human＇s health and life. Currently, a key focus for the medical researchers is to find out effective ways to prevent or treat these heart diseases. ARC （apoptosis repressor with caspase recruitment domain） is the first anti-apoptotic protein so far identified to be highly and specifically expressed in the cardiac tissue. ARC could be structurally phosphorylated and involved in various signaling pathways during apoptosis.