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腺相关病毒在肝脏移植应用的研究进展 被引量:1

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摘要 腺相关病毒(AAV)载体已成为当前基因治疗中最有潜力的病毒载体,在肝移植面临的缺血再灌注损害、免疫排斥反应等问题的基因治疗中发挥其独具的优势.他安全,无致病性,低免疫原性,高效转染肝脏并且目的基因长期表达.同时AAV用于肝移植基因治疗又涉及到一些问题,如肝移植中不可避免的缺血再灌注损伤、AAV目的基因表达的峰值延迟现象以及AAV与肿瘤发生的关系等,本文就以上问题进行综述.
作者 邰升 苏志雷
出处 《世界华人消化杂志》 CAS 北大核心 2006年第22期2155-2158,共4页 World Chinese Journal of Digestology
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