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神经系统中富含亮氨酸重复结构的蛋白 被引量：4

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摘要 从细菌到哺乳动物,多种物种的神经系统内都存在有一3D结构为马蹄形的富亮氨酸重复结构(LRR)蛋白,其主要在信号转导,细胞黏连,神经系统发育等过程中起作用.过去的几年内,在无脊椎动物及脊椎动物神经系统内发现了许多具LRRs的蛋白,它们参与了多种神经生理活动.对这些蛋白的功能作进一步分析,有助于揭示该蛋白家族的分子作用机制,并对进一步认识神经系统的发育等重要生理活动有所裨益.
作者 李欣 陈芳进 刘少君
机构地区 军事医学科学院基础医学研究所
出处 《第四军医大学学报》 北大核心 2006年第17期1624-1629,共6页 Journal of the Fourth Military Medical University
基金 国家自然科学基金面上项目(30400165)
关键词 神经系统 富亮氨酸重复 蛋白相互作用 功能
分类号 Q189 [生物学—神经生物学]
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参考文献29

  • 1Takahashi N,Takahashi Y,Putnam FW.Periodicity of leucine and tandem repetition of a 24-amino acid segment in the primary structure of leucine-rich 2-glycoprotein of human serum[J].Proc Natl Acad Sci USA,1985,82(7):1906-1910.
  • 2O'Shea EK,Rutkowski R,Kim PS.Evidence that the leucine zipper is a coiled coil[J].Science,1989,243(4890):538-542.
  • 3Kobe B,Deisenhofer J.The leucine-rich repeat:A versatile binding motif[J].Trends Biochem Sci,1994,19 (10):415-421.
  • 4Kobe B,Kajava A.The leucine-rich repeats as a protein recognition motif[J].Curr Opin Struct Biol,2001,11(6):725-732.
  • 5Kobe B,Deisenhofer J.Crystal structure of porcine ribonuclease inhibitor,a protein with leucine-rich repeats[J].Nature,1993,366(6457):751-756.
  • 6Rose D,Zhu X,Kose H,et al.Toll,a muscle cell surface molecule,locally inhibits synaptic initiation of the RP3 motoneuron growth cone in Drosophila[J].Development,1997,124(8):1561-1571.
  • 7Wu W,Wong K,Jiang ZH,et al.Guidance of neuronal migration in the olfactory system by the secreted protein Slit[J].Nature,1999,400(6742):331-336.
  • 8Battye R,Stevens A,Perry RL,et al.Repellent Signaling by Slit Requires the Leucine-Rich Repeats[J].J Neurosci,2001,21(12):4290-4298.
  • 9Nose A,Takeichi M,Goodman CS.Ectopic expression of connectin reveals a repulsive function during growth cone guidance and synapse formation[J].Neuron,1994,13(3):525-539.
  • 10Shishido E,Takeichi M,Nose A.Drosophila Synapse Formation:Regulation by Transmembrane Protein with Leu-Rich Repeats,CAPRICIOUS[J].Science,1998,280(5372):2118-2121.

二级参考文献13

  • 1CHEN M S, HUBER A B, VAN DER HAAR M E, et al.Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature, 2000,403(6768): 434 - 439.
  • 2MCKERRACHER L, DAVID S, JACKSON D L, et al,Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth. Neuron, 1994,13(4): 805 - 811.
  • 3GRANDPRE T, LI S, STRITTMATTER S M. Nogo-66 receptor antagonist peptide promotes axonal regeneration.Nature, 2002, 417(6888): 547 - 551.
  • 4WANG K C, KOPRIVICA V, KIM J A, et al. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature, 2002, 417(6892): 941 -944.
  • 5GST Gene Fusion System Handbook, Amersham Biosciences,2002. 9 - 26.
  • 6LAGENAUR C, LEMMON V. An Ll-like molecule, the 8D9 antigen, is a potent substrate for neurite extension.Proc Natl Acad Sci USA, 1987, 84(21): 7753 - 7757.
  • 7LEI G, XUE S, CHERY N, et al. Gain control of N-methyl-D-aspartate receptor activity by receptor-like protein tyrosine phosphatase alpha. EMBO J, 2002, 21(12): 2977 -2989.
  • 8XIAO Z C, TAYLOR J, MONTAG D, et al. Distinct effects of recombinant tenascin-R domains in neuronal cell functions and identification of the domain interacting with the neuronal recognition molecule F3/11. Fur J Neurosci, 1996,8(4): 766 - 782.
  • 9MIKOL D D, STEFANSSON K. A phosphatidylinositollinked peanut agglutinin-binding glycoprotein in central nervous system myelin and on oligodendrocytes. J Cell Biol,1988, 106(4): 1273 - 1279.
  • 10HABIB A A, GULCHER J R, HOGNASON T, et al. The OMgp gene, a second growth suppressor within the NF1 gene. Oncogene. 1998.16(12): 1525 - 1531.

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第四军医大学学报
2006年 第17期

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