影响新生儿应激性溃疡预后因素分析

Analysis of Correlative Factors of Neonatal Stress Ulcer Prognosis

目的分析新生儿应激性溃疡出血病程与预后的因素。方法对NICU收治的应激性溃疡出血新生儿54例,根据出血持续时间、是否需要输血和临床转归分成轻度组(出血病程≤5 d)和重度/未愈组[出血病程>5 d,和(或)需要输血,和(或)未愈死亡病例]。比较两组性别、胎龄和出生体质量及新生儿急性生理学评分Ⅱ(SNAPⅡ)和新生儿急性生理学评分围生期补充Ⅱ(SNAP-PEⅡ)差异。结果两组SNAPⅡ和SNAP-PEⅡ评分有显著差异(χ2=15.207,10.311 P均<0.05);两组性别、胎龄和出生体质量则无统计学差异。结论SNAPⅡ和SNAP-PEⅡ是反映新生儿入院时生理学状态的客观评分系统,其与新生儿应激性溃疡出血病程和预后存在一定关系,临床可利用该评分值对新生儿应激性溃疡出血病程和预后做出预测。

Objective To analyze the correlative factors of prognosis of neonatal stress - induced ulcer bleeding. Methods Fifty four cases of NICU admitted stress- induced ulcer bleeding newborns were divided into mild group and severe group according to bleeding endurance, transfusion requirement, and clinical turnover. Compared with gender, gestational age, birth weight, and score for neonatal acute physiology （SNAP） Ⅱ and score for neonatal acute physiology Ⅱ perinatal extension （SNAP- PE） Ⅱ of two groups. Results Based on the output of SPSS statistical package, the SNAP Ⅱ and SNAP - PE Ⅱ had a significant deviation between two subgroups （χ2 = 15. 207, 10.311 all P〈 0.05）. However, the gender, gestational age and birth weight between them had no statistical different. Conclusion SNAP Ⅱ and SNAP - PE v is an objective scoring system reflecting neonates physiological status on admission, prove associated with turnover and course of neonatal stress - induced ulcer bleeding, which can be probably used as a predictor of the prognosis of neonatal stress ulcer bleeding,as well as severity of disease and in- hospital neonatal mortality.