羟丙基甲基纤维素对磷酸钙水泥注射性能的影响

Effect of hydroxypropyl methyl cellulose on injectability of calcium phosphate cement

[目的]研究羟丙基甲基纤维素对磷酸钙骨水泥可注射性的影响。[方法]用注射能力系数法和稠度测定法对含不同浓度HPMC（0～4％）的CPC的注射性能进行评价。[结果]增加HPMC的浓度，CPC的注射性能也增加。HPMC在2％时，注射性能最好，注射能力系数达95％，稠度最低，对水泥的固化时间无明显影响。HPMC超过3％后注射性能开始下降，至4％时注射能力系数降至90％。[结论]适当浓度的HPMC可以很好的改善CPC的流变学性能，增加其可注射性能，适于微创骨科的应用。

[ Objective] To study the influence of hydroxypropyl methyl cellulose （HPMC） on injectability of calcium phosphate cements （CPC）. [ Method ] Calcium phosphate cement （ICPC） with different content of HPMC （0 -4% ） was prepared. Injectability coefficient and consistency were tested to evaluate the injectability of the cements. [ Result] Injectability increased as HPMC content increased. CPC injectability coefficient reached to 95% with lowest consistency when HPMC increased to 2%. CPC with 2% HPMC could be injected from syringe completely. Injectability began decrease when HPMC beyond 3%. Injectability decreased to 90% as HPMC increased to 4% ,2% HPMC increased the injectability and decreased the consistency significantly, without any influence of setting time. [ Conclusion] Rheology and injectability of CPC can be improved by HPMC significantly,Injection of CPC with 2% HPMC can be used for mini -invasive orthopedic surgery.