摘要
目的:观察接种肿瘤细胞不同时间,给予当归补血汤的抗肿瘤作用。方法:建立荷瘤小鼠(EL-4瘤株)动物模型,当归补血汤煎剂灌胃。观察肿瘤大小和小鼠生存时间。结果:肿瘤接种当日给药组和肿瘤直径0.3cm组与空白对照组比较肿瘤生长速度显著减慢(p<0.05),生存时间显著延长(p<0.05);肿瘤直径0.6cm组与空白对照组比较肿瘤生长速度无差异(p>0.05),生存时间无明显延长(p>0.05);且不同时间用药组比较,各观测指标差异显著(p<0.05)。结论:预防性及肿瘤早期单独应用当归补血汤治疗有一定疗效。
Objective: To investigate the anti tumor effects of Danggui Buxue Tang (DBT) on tumor - bearing mice at various times after inoculation with EL- 4 cells. Methods: C57BL/6 mice were inoculated with EL - 4 ceils, and DBT were given. Tne changes of tumor mass were scaled, and survival time were analyzed. Results: After the treatment of DBT, the tumor grew slowly ( p 〈 0.05), murine survival time was lengthened in DBT group and 0.3cm group, compared with control group ( p 〈 0.05), but there wash' t significant change in 0.6cm group( p 〈 0. 05). Conclusion: DBT has certain inhibiting effects on tumor in C57BL/6 mice, when tumor- bearing mice were given preventive treatment, or treated in the early time of tumor.
出处
《现代生物医学进展》
CAS
2006年第9期31-32,35,共3页
Progress in Modern Biomedicine
关键词
当归补血汤
荷瘤小鼠
抗肿瘤
Danggui Buxue Tang
Tumor- beating mice
Anti tumor