当归补血汤抑制荷瘤小鼠肿瘤生长的作用

The inhibiting effect of Danggui Buxue Tang on tumor's growth of tumor-bearing mice

目的：观察接种肿瘤细胞不同时间,给予当归补血汤的抗肿瘤作用。方法：建立荷瘤小鼠(EL-4瘤株)动物模型,当归补血汤煎剂灌胃。观察肿瘤大小和小鼠生存时间。结果：肿瘤接种当日给药组和肿瘤直径0．3cm组与空白对照组比较肿瘤生长速度显著减慢(p＜0．05),生存时间显著延长(p＜0．05)；肿瘤直径0．6cm组与空白对照组比较肿瘤生长速度无差异(p＞0．05),生存时间无明显延长(p＞0．05)；且不同时间用药组比较,各观测指标差异显著(p＜0．05)。结论：预防性及肿瘤早期单独应用当归补血汤治疗有一定疗效。

Objective： To investigate the anti tumor effects of Danggui Buxue Tang （DBT） on tumor - bearing mice at various times after inoculation with EL- 4 cells. Methods： C57BL/6 mice were inoculated with EL - 4 ceils, and DBT were given. Tne changes of tumor mass were scaled, and survival time were analyzed. Results： After the treatment of DBT, the tumor grew slowly （ p 〈 0.05）, murine survival time was lengthened in DBT group and 0.3cm group, compared with control group （ p 〈 0.05）, but there wash＇ t significant change in 0.6cm group（ p 〈 0. 05）. Conclusion： DBT has certain inhibiting effects on tumor in C57BL/6 mice, when tumor- bearing mice were given preventive treatment, or treated in the early time of tumor.