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蛋白质去糖基化酶及其应用 被引量:1

Deglycosylation enzyme of proteins and its application
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摘要 果糖氨氧化酶和果糖氨激酶能催化去糖基化反应而释放出自由氨基。本文主要探讨阿马多里酶的生物化学特征。如结构和功能的关系,动力学机制和底物的特异性,并探讨这些酶的生物作用和在蛋白中去糖基化中的应用,希望为糖基化相关疾病的治疗提供很好的治疗手段。 Fmctesyl lysine oxidase and fructose lysine 3 - phesphokinase can catalyze the deglycosylation reaction and generate free amino groups.This paper reviews the biochemical properties of these "amadoriase" enzymes, such as structural- function relationship, kinetic mechanism, and substrate specificity, as well as their biological roles and applications in the protein deglycosylation, which is expected to offer a promising therapeutic approch for the prevention and treatment of glycesylation related diseases.
出处 《现代生物医学进展》 CAS 2006年第9期90-92,共3页 Progress in Modern Biomedicine
关键词 去糖基化酶 阿马多里酶 衰老 Deglycosylation enzyme Amadoriase Aging
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同被引文献11

  • 1刘红霞,苏卫,张连峰.α-甘露糖苷酶研究进展[J].中国比较医学杂志,2006,16(11):697-702. 被引量:12
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