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蛋白质去糖基化酶及其应用 被引量：1

Deglycosylation enzyme of proteins and its application
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摘要 果糖氨氧化酶和果糖氨激酶能催化去糖基化反应而释放出自由氨基。本文主要探讨阿马多里酶的生物化学特征。如结构和功能的关系,动力学机制和底物的特异性,并探讨这些酶的生物作用和在蛋白中去糖基化中的应用,希望为糖基化相关疾病的治疗提供很好的治疗手段。 Fmctesyl lysine oxidase and fructose lysine 3 - phesphokinase can catalyze the deglycosylation reaction and generate free amino groups.This paper reviews the biochemical properties of these ＂amadoriase＂ enzymes, such as structural- function relationship, kinetic mechanism, and substrate specificity, as well as their biological roles and applications in the protein deglycosylation, which is expected to offer a promising therapeutic approch for the prevention and treatment of glycesylation related diseases.
作者 刘慧敏 印大中
机构地区 湖南师范大学生命科学学院
出处 《现代生物医学进展》 CAS 2006年第9期90-92,共3页 Progress in Modern Biomedicine
关键词 去糖基化酶 阿马多里酶 衰老 Deglycosylation enzyme Amadoriase Aging
分类号 Q55 [生物学—生物化学]
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参考文献15

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同被引文献11

  • 1刘红霞,苏卫,张连峰.α-甘露糖苷酶研究进展[J].中国比较医学杂志,2006,16(11):697-702. 被引量：12
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  • 6Shi X,KARKUT T,CHAMANKHAH M,et al. Optimal conditions for the expression of a single -chain antibody (scFv) gene in P. pastoris [J]. Protein Expr Purif, 2003,28 (2) : 321-330.
  • 7WU SX and GEOFFREY J. High efficiency transformation by electroporation of Pichia pastoris pretreated with lithium acetate and dithiothreitol [J]. Bio-Techniques, 2004,36 : 152- 154.
  • 8ROGER K B, FRANCIS J C. Glycosylation of Pichia pastoris-derived proteins [J]. Biotechnol Appl Biochem, 1999,30 : 193- 200.
  • 9TAKAHSAHI K, TAKAI T, YASUHARA T. Effects if site-directed mutagenesis in the cysteine residues and the N-glycosylation motif in recombinant Der fl on secretion and protease activity [J ]. Int Arch Allergy Immunol, 2001, 124(4) :454.
  • 10贺建宇,曹立环,查锡良.N-糖链合成抑制剂对NIH3T3细胞粘附作用和整合蛋白表达的影响[J].中国生物化学与分子生物学报,1999,15(1):105-108. 被引量：3

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现代生物医学进展
2006年 第9期

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