血脂蛋白(a)预测儿童激素敏感型肾病综合征复发的研究

Plasma Lipoprotein(a) Concentration Predicts Relapse of Steroid-Sensitive Nephrotic Syndrome in Children

目的:探讨血脂蛋白质(a)[Lp(a)]是否可以预测儿童激素敏感型肾病综合征复发的临床参考指标。方法:50例健康儿童为对照组,22例激素敏感型肾病综合证(SSNS)为研究组,研究组又分为2组:非勤复发肾病综合征组(IRNS)为12例非勤复发者(6个月内少于2次或1年内少于3次),勤复发肾病综合征组(FRNS)为10例勤复发者(6个月内2次或1年内大于3次)。测定研究对象血浆脂质代谢指标包括总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(Apo A1)、载脂蛋白B(Apo B)、载脂蛋白E(Apo E)和Lp(a)。结果:血浆TC、TG、HDL-C、LDL-C、Apo A1、Apo B and Apo E浓度在FRNS和IRNS组无明显差异,而FRNS组血浆Lp(a)较IRNS组升高(813.7±354.6vs356.9±267.8mg/L,P<0.01)。结论:Lp(a)可以作为预测儿童激素敏感型肾病综合征复发的临床参考指标。

Objective： To study whether plasma lipoprotein（a）[（Lp（a）] can predict relapse of steroid- sensitive nephritic syndrome（NS） in the children. Methods： Plasma lipid including total cholesterol（TC）, triglyceride（TG）, HDL cholesterol（HDL - C）, LDL- cholesterol（LDL - C）, Apo A1, Apo B, Apo E and Lp（a） level were investigated in 50 health controls as well as 22 children with steroid - sensitive iNS. Patients were divided into two groups. IRNS group consisted of 12 cases with infrequent relapse（IR： 〈2 in 6 months or 〈3 in a year） and FRNS group consisted of 10 patients with frequent relapse （FR：2 in 6 months or 3 in a year）. Results：The concentrations of plasma TC, TG, HDL- C, LDL- C,Apo M ,Apo B and Apo E were not significantly different between FRNS and IRNS groups, but the concentration of plasma Lp（a） in FRNS group was significantly higher than that in IRNS group（813.7 ± 354.6 vs 356.9 ± 267.8 rag/L, P〈0.01）. Conclusion： High Lp（a） may predict future relapse of NS.