摘要
目的:探讨大剂量爱维治(Actovegin)对糖尿病周围神经病变(DPN)的疗效及安全性。方法:60例DPN患者随机分为三组,大剂量组给予爱维治2 000mg,常规剂量组给予爱维治800 mg,均溶于500 m l等渗盐水中静脉滴注;对照组给予前列地尔10μg溶于100m l等渗盐水中静脉滴注,均为1次/d,共15 d,观察治疗前后主要症状和神经电生理的变化。结果:大剂量爱维治组主要症状改善明显优于常规剂量组和对照组,周围神经传导速度提高较常规剂量组和对照组也有显著性差异(P<0.05),未见不良反应。结论:大剂量爱维治比常规剂量更能改善DPN临床症状及周围神经传导速度,安全性较好。
Objective: To study the efficacy and safety of large dose Actovegin in patients with diabetic peripheral neuropathy(DPN). Methods:Sixty patients of DPN were divided into three groups randomly : Large dose group ( Actovegin 2 000 mg/day) , Routine dose group ( Actovegin 800 mg/day). Control group, Lipo PGE1 10μg/day. Symptoms and nerve conduct velocity were observed. Results: The rate of symptoms improvement and nerve conduct velocity improvement are higher in large dose group than those in other two groups. Conclusion: Large dose Actovegin can improve peripheral nerve conduct velocity significantly and is safe for use.
出处
《医学研究生学报》
CAS
2006年第9期814-816,共3页
Journal of Medical Postgraduates
关键词
糖尿病
周围神经
传导速度
爱维治
Diabetes
Peripheral nerve
Conduct victory
Actovegin