COX-2蛋白和mRNA表达与胃癌生物学行为的关系

The relationship between gene-expressions of COX-2 and gastric carcinoma biological behavior

目的探讨环氧合酶-2(COX-2)蛋白和mRNA表达与胃癌生物学行为的关系。方法采用免疫组织化学SP法和原位杂交检测57例胃癌组织中COX-2蛋白和mRNA的表达情况。结果COX-2蛋白和mRNA表达均与肿瘤大小、浆膜侵犯、淋巴结转移、TNM分期及Lauren分型明显相关,而尚不能认为与组织分化相关。结论检测COX-2基因对判断胃癌的生物学行为有一定价值;COX-2基因在胃癌的发展过程中可能起重要作用。

Objective To study the COtTelation between gene-expressions of COX -2 and gastric carcinoma biological behavior. Methods lmmunohistochemical technique and in situ hybridization technique were used to examine the protein and mRNA expressions of COX-2 in 57 specimens of gastric carcinoma. Results There were statistically significant differences of the protein and mRNA expressions of COX-2 in groups of tumor size,serosal invasion, lymph node metastasis, TNM staging and Lauren type. There was no statistically significant difference of the protein and mRNA expression of COX-2 in group of histological. Conclusion COX-2 gene detection can evaluate the gastric carcinoma biological behavior. COX-2 gene may play an important role in progress of gastric carcinoma.