非小细胞肺癌中COX-2、VEGF和MVD的表达及其意义

Study on the Association Between COX-2,VEGF and MVD Expression in Non-small Cell Lung Cancer

目的探讨环氧合酶-2(COX-2)与血管内皮生长因子(VEGF)在非小细胞肺癌(NSCLC)中的表达及其与生物学行为的关系。方法58例临床资料完整的肺癌手术切除标本,采用免疫组化方法检测其中COX-2、VEGF及微血管密度(MVD)的表达情况。结果58例Nsclc的COX-2阳性表达率75.9%(44/58),VEGF的阳性表达率82.7%(48/58),临床分期高的COX-2,VEGF表达及MVD计数要高于临床分期低的肺癌,有淋巴结转移的COX-2,VEGF的表达及MVD计数要高于无淋巴结转移的肺癌组织,差别均具有统计学意义(P<0.05),并且COX-2的表达与VEGF、CD34的表达成正相关。结论COX-2、VEGF在人肺癌组织中均有高表达,COX-2、VEGF和MVD三者在肿瘤血管生成及肿瘤浸润转移中可能起协同作用,可作为评价NSCLC预后的共同指标。

Objective To evaluate the expression of cyclooxygenase-2 （COX-2）, vascular endothelial growth factor （VEGF） and microvessl density （MVD） in human non-small cell lung cancer （NSCLC） and investigate its correlation with histopathological features. Methods The expression of COX-2, VEGF and MVD in cancer tissues in 58 NSCLC patients with complete clinical data was evaluated by immunohistochemitry methods. Results The positive rates of COX-2 and VEGF in NSCLC were 75.9 % and 82.7 %. The expression of COX-2, VEGF, MVD have significant correlation with some pathological characteristics such as TNM classification and lymph nodes metastasis. COX-2 expession are positive correlated with VEGF and CD34 expression. Conclusion COX-2, VEGF and MVD are synergetic in tumor angiogenesis, invision and metastases in NSCLC. They may be used as a hopeful marker for predicting the metastasis potential of NSCLC.