初发2型糖尿病患者大血管病变与C反应蛋白的关系

目的探讨C反应蛋白(CRP)与初发2型糖尿病(T2DM)大血管病变的关系。方法将222例初发T2DM患者根据有无大血管病变(MD)分为两组MD组与非MD组,对两组患者的多项临床指标及CRP水平进行比较及相关分析。结果⑴初发T2DM患者MD组的CRP水平显著高于非MD组(P=0.022)。⑵CRP水平与平均动脉内膜—中层厚度呈显著正相关(r=0.152,P=0.018)。结论CRP与初发T2DM大血管病变的发生、发展密切相关,提示CRP可能是导致T2DM患者早期大血管病变的危险因素之一。

Objective To investigate the relationship between C - reactive protein （CRP）and macrovascular disease in newly diagnosed type 2 diabetic subjects. Methods According to arterial intima - media thickness（IMT） measured by color duplex ultrasonography, we divided 222 cases of type 2 diabetic patients （newly diagraosed） into two groups： one group were 90 cases with macrovascular disease （MD） ; the other group were 132 cases without macrovascular disease （non- MD）. Then various clinical data （including CRP） between the two groups were compared and their correlation was analysed. Results （1） CRP level was significantly higher in MD group compared with those in non - MD group. （2） The IMT mean showed a significant positive correlation with CRP level. Conclusion Our results show that CRP is a risk factor in the initiation of macrovascular disease in type 2 diabetes mellitus.