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前列腺癌的神经内分泌分化 被引量：7

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摘要 一、良性前列腺中的神经内分泌细胞 正常前列腺主要由分泌细胞和基底细胞组成，可在HE染色下由普通显微镜分辨。另外还有散在微量的神经内分泌细胞（neuroendocfine cell，NE细胞），该细胞仅能由电镜分辨，或者通过免疫组织化学方法用特异性标记物如嗜铬粒素A（CgA）、突触素（Syn）、神经元特异性烯醇化酶（NSE）等识别。前列腺的NE细胞具有上皮性、神经性和内分泌性特征，散在分布于前列腺，但在移行区和外周区比在中心区更多见。NE细胞的这种分布，可能与前列腺增生和前列腺癌有关。
作者 吴澄宇 那彦群 JorgeL.Yao P.AnthonydiSant'Agnese 黄教悌
机构地区 Department of Pathology University of Rochester Medical Center Rochester New York U S A 北京大学医学部泌尿外科
出处 《中华病理学杂志》 CAS CSCD 北大核心 2006年第9期565-567,共3页 Chinese Journal of Pathology
关键词 前列腺癌 神经内分泌分化 神经内分泌细胞 神经元特异性烯醇化酶 免疫组织化学方法 NE细胞 特异性标记物 正常前列腺
分类号 R737.25 [医药卫生—肿瘤]
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参考文献21

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同被引文献72

  • 1谢立平,秦杰,郑祥毅,沈华峰,陈昭典,蔡松良,张志根,丁伟,任国平,王丽君,余心如.481例前列腺癌患者年龄与病理构成分析[J].中华男科学杂志,2005,11(6):428-430. 被引量：36
  • 2张青云,徐建军,王雅明.人神经元特异性烯醇化酶在肿瘤细胞系中的表达检测及意义[J].中华检验医学杂志,2005,28(7):728-731. 被引量：12
  • 3Yuan TC,Veeramani S.Lin FF.et al.Androgen deprivation in-duees human prostate epithelial neuroendocfine differemiation of androgen-sensitive LNCaP cells[J].Endocrine-related Cancer,2006,13:151-167.
  • 4Yao JL,Madeb R,Bourne PA,et al.Small cell carcinoma of the prostate:an immunohistochemical study[J].Am J Sug Pathol,2006,30:705-712.
  • 5Were Wang,Jonathan I.Epstein.Small cell carcinoma of the prostate:a morphologic and immunohistoehemical study of 95 cases[J].Am J Stag Pathol,2008,32:65-71.
  • 6Katsuyuki Sano,Keikoku Miyai,and Sachiko Yoshids.Small cell carcinoma of the prostate:a case report[J].Int J Urol,1997,4:321-323.
  • 7Stangelberger A,Schally AV,Varga jL,et al.Antagonists of growth horraone releasing hormone(GHRH)and of bombesin/gastrin releasing peptide(BN/GRP)suppress the expression of YEGF,bFGF,and receptors of the EGF/HER family in PC-3 and DU-145 human androgen-independent prostate cancers[J].The Prostate,2005,64:303-315.
  • 8May M,Siegsmund M,Hammermann F,et al.Prognostic significance of proliferation activity and neuroendocrine differenfiatiOn to predict treatment failure after radical prostatectomy[J].Urol Nephml,2007,41:375-381.
  • 9Korkes F,Gasperini R,Korkes KL,et al.Testicular metastases:a poor prognostic factor in patients with advanced prostate cancer.World J Urol,2009,27:113-115.
  • 10王静文,姚阳.前列腺癌神经内分泌化与内分泌治疗耐药的关系[J].中国癌症杂志,2007,17(9):729-732. 被引量：1

引证文献7

二级引证文献18

中华病理学杂志
2006年 第9期

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