GSTM1基因多态性与宫颈癌遗传易感性的关系

Association of single nucleotide polymorphism in glutathione S-transferase with susceptibility to cervical cancer

目的探讨GSTMI基因多态性与宫颈癌遗传易感性的关系。方法采用多重PCR技术分析130例经病理确诊的宫颈癌病人（病例组）和130例同一地区的健康汉族妇女（对照组）的GSTMI基因型。结果宫颈癌病例组的GSTM1基因纯合缺失率（59．2％）高于对照组（43．9％）差别有显著的统计学意义（x^2=4．986，P=0．026）；GSTM1基因型在各年龄组间分布无差异。结论GSTM1基因纯合缺失能增加宫颈癌发生的危险性，GSTM1基因多态性与宫颈癌遗传易感性密切相关，GSTM1基因纯合缺失是先天遗传而非突变造成的。

Objective To investigate the association of single nucleotide polymorphism in glutathione S-transferase-M1 with susceptibility to cervical cancer. Methods The genotype of GSTM1 gene promoter region was determined by multi-PCR method in 130 cervical cancer patients （cases group） and 130 unrelated healthy women （control group）. Rusults The frequency of GSTM1 null genotype in cases （59.2%） was significantly higher than in controls （43.9%）. There showed no significant different in frequency of GSTM1 null genotype in different age groups. Conclusions GSTM1 null genotype could increase risk of cervical cancer. GSTM1 promoter polymorphism is an important risk factor with susceptibility to cervical cancer.