EB病毒与霍奇金淋巴瘤相关性的研究进展

Research advances on the relationship between Epstein-Barr virus and Hodgkin＇s lymphomas

EB病毒（EBV）与霍奇金淋巴瘤（HL）的发生密切相关，其相关性受年龄，性别，民族／种族，地理环境以及社会经济状况的影响。在经典型HL的肿瘤细胞中，EBV的检出率为20％-80％，尤其是在西方国家。病毒有两种不同的生活方式：潜伏期，只表达有限的基因；裂解周期，多数病毒基因被表达并产生病毒颗粒。EBV潜伏基因的表达产物在HL的发生中具有重要作用，肿瘤EB病毒的状态与HL的临床预后和治疗均有关联。

Epstein-Barr virus （EBV） is significantly associated with Hodgkin＇s lymphomas （HL） This association is influenced by age,sex,nation/ethnicity, geography and socioeconomic conditions. EBV is detected in 20%-80% tumor cell of classic HL, in particular, in Western countries. The virus has two distinct life styles： latency, during which a limited number of genes are expressed, and the lytic cycle, when the majority of viral genes are expressed and virions are produced.The production of EBV gene expression during the latency plays an important role in the pathogenesis of HL. The status of EBV is linked with outcome and therapeutical response of HL.