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MGB探针检测广州地区汉族人群糖尿病亚甲基四氢叶酸还原酶基因677C→T多态性 被引量：3

Detection of the 677 C→T variant of MTHFR gene in Chinese diabetic patients with fluorescent MGB probe real-time PCR
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摘要 186例T2DM,46例T1DM和110例正常对照的研究显示,糖尿病微血管病变与MTHFR基因677C→T多态性的显著相关性,仅见于T2DM,不见于T1DM。TaqMan-MGB探针技术是检测677C→T多态性的良好平台。 The study of T2DM （n=186） and T1DM （n=46） as well as normal control （n= 110） showed that diabetic microangiopathy （DMA） was correlated with MTHFR gene 677 C→T polymorphism only in T2DM, but not in T1DM. And fluorecent MGB probe real-tlme PCR technique is good for diagnosis of 677 C→T mutation.
作者 史成军 何蕴韶 程钢 王伟毅 刘娟 徐杰 符立梧
机构地区 中山大学达安基因诊断中心
出处 《中国糖尿病杂志》 CAS CSCD 北大核心 2006年第4期258-260,共3页 Chinese Journal of Diabetes
关键词 糖尿病 亚甲基四氢叶酸还原酶 基因 MGB探针 Diabetes mellitus Methylene tetrahydrofolate reductase Gene MGB probe
分类号 R587.1 [医药卫生—内分泌]
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参考文献5

  • 1孙家忠,徐焱成,朱宜莲,鲁红云,邓浩华,范幼筠,孙苏欣,张颖.糖尿病视网膜病MTHFR基因多态性及其与血浆同型半胱氨酸水平的关系[J].中华医学遗传学杂志,2003,20(2):131-134. 被引量：5
  • 2Ksiazek P,Bednarek SA,Buraczynska M.The C677T methylene tetrahydrofolate reductase gene mutation and nephropathy in type 2 diabetes mellitus.Med Sci Monit,2004,10:47-51.
  • 3Wilcken B,Bamforth F,Li Z,et al.Geographical and ethnic variation of the 677C-T allele of 5,10 methylene tetrahydrofolate reductase.findings from over 7000 newborns from 16 areas world wide.Med Genet,2003,40:619-625.
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  • 5Shcherbak NS,Shutskaya ZV,Sheidina AM,et al.Methylene tetrahydrofolate 2 reductase gene polymorphism as a risk factor for diabetic nephropathy in IDDM patients.Mol Genet Metab,1999,68:375-378.

二级参考文献15

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共引文献4

同被引文献29

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二级引证文献12

中国糖尿病杂志
2006年 第4期

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