摘要
免疫组化染色显示,正常大鼠的心肌间隙连接蛋白43(Cx43)大量表达(平均灰度值230±5),分布在相邻细胞的连接处和闰盘部位。STZ诱导的糖尿病大鼠的Cx43表达明显减少(平均灰度值193±4)(P<0·01),且分布紊乱。这可能相关于糖尿病心肌病变的发病。
The immunohistochemical staining showed the connexin 43 (Cx43) was strongly ex pressed (average gray value, AGV=230±5), distributed at junction area and intercalated disks of cardiocytes in normal rats, and much less expressed ( AGV 193±4) ( P〈 0.01 ) and distribution-disorganized in STZ-induced diabetic rats. This may be associated with the pathogenesis of diabetic myocardial lesions.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2006年第4期288-289,共2页
Chinese Journal of Diabetes
基金
广东省中医药科研课题(101107)