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实验性糖尿病心肌病变心肌连接蛋白43的意义

The role of connexin 43 of heart tissues in experimental diabetic myocardial lesion
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摘要 免疫组化染色显示,正常大鼠的心肌间隙连接蛋白43(Cx43)大量表达(平均灰度值230±5),分布在相邻细胞的连接处和闰盘部位。STZ诱导的糖尿病大鼠的Cx43表达明显减少(平均灰度值193±4)(P<0·01),且分布紊乱。这可能相关于糖尿病心肌病变的发病。 The immunohistochemical staining showed the connexin 43 (Cx43) was strongly ex pressed (average gray value, AGV=230±5), distributed at junction area and intercalated disks of cardiocytes in normal rats, and much less expressed ( AGV 193±4) ( P〈 0.01 ) and distribution-disorganized in STZ-induced diabetic rats. This may be associated with the pathogenesis of diabetic myocardial lesions.
出处 《中国糖尿病杂志》 CAS CSCD 北大核心 2006年第4期288-289,共2页 Chinese Journal of Diabetes
基金 广东省中医药科研课题(101107)
关键词 心肌病变 糖尿病 连接蛋白43 免疫组织化学 Diabetic cardiomyopathy Connexin 43 Immunohistochemistry
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参考文献5

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