慢性自身免疫性甲状腺炎患儿糖代谢临床研究

Clinical study on carbohydrate metabolism of the children with Hashimoto thyroiditis

目的探讨慢性自身免疫性甲状腺炎(Hashimoto’sthyroiditis,HT)患儿的胰岛自身抗体及糖代谢的变化。方法通过对40例HT患儿的胰岛自身抗体(GAD、IA-2)、胰岛素、血糖水平的检测,与正常患儿相比较,探讨两者的相关性。结果40例HT患儿中,胰岛自身抗体GAD均阴性,有5例IA-2阳性,与对照组相比差异有显著性。餐后2h血糖、空腹胰岛素、餐后2h胰岛素均有升高,与对照组有显著变化。结论HT患儿有胰岛功能及胰岛自身抗体变化,提示有发展为多腺体自身免疫性疾病的可能。

Objectives To study the change of the insulin-autoantibody and carbohydrate metabolism in children with chronic autoimmune thyroiditis （Hashimoto thyroiditis,HT）. Methods The levels of insulin-autoantibody （GAD,IA-2） ,insulin and blood glucose were determined in 40 HT children and 40 normal children. The comparison of these results was made and the differences were then discussed. Results GAD was negative in all 40 patients but 5 were IA-2 positive with significant difference from the control. And the levels of fasting insulin,postprandial 2-hour insulin and blood sugar were significantly higher than that of the control. Conclusions The change of islet function and insulin- autoantibody was existed in HT children,suggesting that the disease might evolve to autoimmune polyglandular syndrome.