摘要
目的观察玉泉丸对2型糖尿病患者促炎细胞因子干预的影响。方法90例2型糖尿病患者按2∶1随机分成治疗组和对照组,两组均在饮食控制、运动等基础治疗基础上加用拜糖苹治疗,治疗组另加服玉泉丸,每次6g,1日4次,疗程3个月,同时观察其C反应蛋白(Creactiveprotein,CRP)、肿瘤坏死因子α(tumornecrosisfactorα,TNFα)、白细胞介素6(interleukin6,IL6)等促炎细胞因子的变化。结果治疗组CRP、TNFα、IL6水平均较治疗前显著降低(P<0.01),两组间CRP、TNFα、IL6治疗前后差值比较差异亦有显著性,治疗组均明显高于对照组(P<0.01)。结论玉泉丸能降低已升高的促炎细胞因子水平。
Objective To observe the effect of Yuquan Pill （YP） on proinflammatory cytokines in patients with type 2 diabetes mellitus （DM2）. Methods Ninety patients with DM2 were randomly divided into the treated group and the control group by the ratio of 2 ： 1. Both groups were treated with Glucobay on the base of dietary and exercise therapy for 3 months, with YP, given to the treated group additionally 6 g four times a day. And the changes of proinflammatory cytokines, including C-reactive protein （CRP）, tumor necrosis factor-α （TNF-α） and interleukin-6 （IL-6）, etc. were observed. Results The levels of serum CRP,TNF-a and IL-6 significantly lowered after treatment in both groups （P 〈 0.01 ）, and the improvement in the treated group was superior to that in the control group （P 〈 0.01）. Conclusion YP could reduce the levels of the increased proin- flammatory cytokines in patients with DM2.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2006年第8期706-709,共4页
Chinese Journal of Integrated Traditional and Western Medicine
