抗甲方加减合西药治疗甲状腺机能亢进症的临床观察

Effect of Combined Therapy of Modified Kangjia Recipe Combined with Western Medicine on Hyperthyroidism

目的观察抗甲方合西药丙基硫氧嘧啶治疗甲状腺机能亢进症(简称甲亢)患者的临床疗效,评价其对甲亢的治疗作用及治疗优势。方法选取符合中医和西医诊断标准的甲亢患者90例,治疗组60例采用自拟抗甲方加减合西药丙基硫氧嘧啶治疗,对照组30例单用西药丙基硫氧嘧啶治疗,疗程均为3个月;观察两组治疗前后血清甲状腺激素、中医症状、体征改善情况及不良反应。结果两组治疗后血清甲状腺激素、中医证候及体征均有改善(P<0.01);治疗组总有效率为93.3%,对照组83.3%,两组比较差异有显著性(P<0.01);改善甲亢心悸、心烦、恶热、多汗、失眠症状两组比较,差异有显著性(P<0.05);不良反应的发生治疗组明显少于对照组。结论抗甲方治疗甲亢疗效满意,中西药联合治疗有明显优势。

Objective To observe the therapeutic effect of combined therapy of modified Kangjia Recipe （KR） and western medicine propylthiouracil （PTU） on hyperthyroidism and to assess its advantage, Methods Ninety patients with hyperthyroidism were divided into the treatment group （TG） and the control group （CG）. The 60 patients in TG treated with KR and PTU, and the 30 patients in CG treated with PTU alone. The treatment course of both groups was 3 months, The serum thyroid hormone （TH） level, clinical symptoms and signs, and adverse reaction were observed before and after treatment, Results The serum TH level, clinical symptoms and signs were significantly improved after treatment in both groups （all P〈 0.01 ）, The total effecrive rate was 93.3% in TG, which was higher than that in CG （83.3%, P〈0.01）; and the efficacy in improving palpitation, fidget, aversion to heat, sweating and insomnia was better in the TG than that in the CG respectively （P〈0.05）. As for the incidence of adverse reaction, it that was lower in the TG than in the CG. Conclusion KD has good efficacy in treating hyperthyroidism, and the combined treatment of Chinese and Western medicine shows obvious advantages.