摘要
目的观察外源性壳聚糖对膝骨性关节炎关节功能的影响,并与透明质酸钠比较。方法将42例膝骨性关节炎随机分为壳聚糖组20例(26膝)和透明质酸钠组22例(28膝),患膝关节腔注射1%壳聚糖2m l或1%透明质酸钠2m l,1个月内注射3次为1个疗程,1年内4个疗程。测定治疗后1、4、7、12个月关节功能指数,检测关节液中IL-1、IL-6和TNF-α水平改变。结果壳聚糖组治疗、4、7、12个月后的关节功能指数分别为8.6±1.8、7.3±1.7、5.6±1.9,显著好于治疗前,第1、4、7、12个月有效率分别为19.2%、42.3%、50.0%和65.4%,但与透明质酸钠组比较无显著区别。两组患者关节液IL-1、IL-6和TNF-α水平均显著低于治疗前。结论外源性壳聚糖与透明质酸钠均能有效缓解膝骨性关节炎的临床症状。
Objective To investigate the effect of ectogenesis chitosan and hyaluronic acid on the joint function of osteoarthritis patients. Methods Forty-two patients suffered from knee osteoarthritis were divided randomly into chitosan group ( 26 osteoarthritis knees of 20 patients ) and hyaluronic acid group ( 28 knees of 22 patients 1. Two millilitre of one percent chitosan or hyaluronic acid was injected into the articular cavity. Three injections were performed within 1 month every course. Four courses were done within 1 year. Joint function index were observed in 1,4,7,12 months after the first injection,and the content of IL-1, IL-6 and TNF-α of joint fluid were detected. Results In chitosan group, the joint function index were higher than that before treatment. The efficient rate in 1 st,4th,7th, 12th month were 19.2% ,42.3% ,50.0% and 65.4% respectively. There was not any difference between these two groups. The level of IL-1, IL-6 and TNF-α decreased significantly after treatment in both groups.Conclusion Ectogenesis chitosan as well as hyaluronic acid has good effect on osteoarthritis.
出处
《创伤外科杂志》
2006年第5期449-451,共3页
Journal of Traumatic Surgery