苯甲酸钠催化合成乙酰水杨酸的研究

Synthesis of acetyl salicylic acid with sodium benzoate as catalytic

用苯甲酸钠催化剂，以水杨酸和乙酸酐为原料合成乙酰水杨酸．结果表明：当水杨酸用量为2．0g，乙酸酐用量为2．8mL，苯甲酸钠用量为水杨酸质量的8％～10％时，在60～65℃条件下反应25～30min，纯化乙酰水杨酸收率可达82．8％．该催化剂具有催化活性高、安全、后处理容易、不污染环境等优点，是一种环境友好催化剂，具有工业开发价值。

Acetyl salicylic acid was catalytic synthesized by the reaction of salicylic acid with acetic anhydride catalyzed by sodium benzoate. The target compound could be obtained in 82.8 % yield after heating of the reaction mixtures（salicylic acid 2.0 g, acetic anhydride 2.8 mL, sodium benzoate 8 % -10%,6 （ w of salicylic acid））, 60- 65℃ reaction for 25- 30 min, which indicated that sodium benzoate was an environmentfriendly catalyst with safety, little pollution and high catalytic performance and could be used in the future industrial applications.