肾病综合征患者血清Ig和补体C_3的测定及临床意义探讨

Clinical significance of immunogloubin and C_3 in patients with nephritic syndrome

目的通过对肾病综合征和其他常见的几类肾脏疾病进行血清免疫球蛋白(Ig)的测定,探讨肾病综合征体液免疫功能的变化。方法采用散射免疫比浊法(nephelometry)和酶联免疫吸附法(ELISA)分别对肾病综合征(NS)、慢性肾小球肾炎(CN)、慢性肾衰竭(CRF)氮质血症期和尿毒症期及正常对照组进行Ig和补体C3的测定。结果NS患者IgG为(5.92±3.71)g/L,明显低于其他各组(P<0.01),而IgM和IgE水平高于其他肾病组及正常对照组(P<0.05),慢性肾衰竭(CRF)尿毒症期血清补体C3水平低于其他各组(P<0.05)。结论血清Ig测定在肾病综合征的诊断和治疗过程中具有重要的临床意义。

Objectives To study the changes of serum Ig and C3 in patients with nephritic syndrome and its clinical significance, Methods The serum IgG, IgA,IgM C3; levels was detected by nephelometry, and the serum IgE level was analyzed l）y ELISA. Results In patients with nephritic syndrome.the levels of serum IgO were significantly lower than that in the group of NS. CRFand normal group（P〈0.01）, and the level IgM and IgE were significantly higher than those in healthy controls and other renal disease group （P〈0.05 respectively）. The level of C3 in CRF- uraemia group was lower than other groups （P〈0.05）. Conclusion The detection of Ig,especially the level of IgG IgM and IgE may have important clinical significance in the diagnosis and treatment of nephritic syndrome.