期刊文献+

单次使用阿奇霉素预防术后倒睫复发:埃塞俄比亚的随机试验

Single-dose azithromycin prevents trichiasis recurrence following surgery:Randomized trial in Ethiopia
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摘要 Background:Trichiasis recurrence following surgery is a serious problem for trachoma programs.Objective:To determine if postoperative treatment with azithromycin compared with topical tetracycline reduces recurrence up to 1 year,and if azithromycin treatment of household members provides additional benefit compared with treating only the surgical patient.Design:A randomized,single-masked,clinical trial was conducted in Ethiopia.A total of 1452 patients with trichiasis were randomized 1:1:1 to the following 3 arms:single-dose(1 g)oral azithromycin alone,single-dose azithromycin for household members(20 mg/kg up to 1 g)plus the patient,or topical tetracycline(twice per day for 6 weeks).Main Outcome Measures:Trichiasis recurrence within 1 year following surgery.Results:The combined azithromycin groups had significantly fewer recurrences,6.9 of 100 person-years overall,compared with topical tetracycline,10.3 of 100 personyears(P=.047).There was no additional reduction in the arm that also treated household members,8.1 of 100 person-years,compared with treating the surgical patients alone,5.8 of 100 person-years(P=.19).Conclusions:In trachoma-endemic areas,a single dose ofazithromycin reduced postoperative trichiasis recurrence rates by one third compared with topical tetracycline.Application to Clinical Practice:In countries where azithromycin is part of the Trachoma Control Program,patients with trachomatous trichiasis should be treated postoperatively to prevent recurrence. Background: Trichiasis recurrence following surgery is a serious problem for trachoma programs. Objective: To determine if postoperative treatment with azithromycin compared with topical tetracycline reduces recurrence up to 1 year, and if azithromycin treatment of household members provides additional benefit compared with treating only the surgical patient. Design: A randomized, single-masked, clinical trial was conducted in Ethiopia. A total of 1452 patients with trichiasis were randomized 1:1: 1 to the following 3 arms: single-dose (1 g) oral azithromycin alone, single-dose azithromycin for household members (20 mg/kg up to 1 g) plus the patient, or topical tetracycline (twice per day for 6 weeks) Main Outcome Measures: Trichiasis recurrence within 1 year following surgery. Results: The combined azithromycin groups had significantly fewer recurrences, 6. 9 of 100 person-years overall, compared with topical tetracycline, 10.3 of 100 personyears (P =0. 047). There was no additional reduction in the arm that also treated household members, 8.1 of 100 person-years, compared with treating the surgical patients alone, 5.8 of 100 person-years (P=0. 19) Conclusions: In trachoma-endemic areas, a single dose ofazithromycin reduced postoperative trichiasis recurrence rates by one third compared with topical tetracycline. Application to Clinical Practice: In countries where azithromycin is part of the Trachoma Control Program, patients with trachomatous trichiasis should be treated postoperatively to prevent recurrence.
出处 《世界核心医学期刊文摘(眼科学分册)》 2006年第9期21-21,共1页 Digest of the World Core Medical Journals:Ophthalmology
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