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脂联素与动脉粥样硬化 被引量:1

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摘要 脂联素为脂肪组织分泌的一种细胞因子,实验证实其具有改善胰岛素抵抗、抗动脉粥样硬化、抗炎等作用。脂联素与动脉粥样硬化具有明显相关性,低脂联素血症与初始的动脉粥样硬化相关,是动脉粥样硬化严重程度的重要标志。动脉粥样硬化是一种炎症过程,而脂联素在多个环节上均有抗炎、抗动脉粥样硬化的作用:脂联素通过抑制动脉粥样硬化因子的产生,抑制血管内皮细胞炎症及黏附,抑制泡沫细胞的形成,抑制血管平滑肌的增殖等多种途径发挥抗动脉粥样硬化的作用。血浆脂联素水平有可能成为预测、诊断冠心病的一个指标,增加脂联素的血浆浓度可能为心血管疾病提供一个全新的治疗手段。
作者 张闽 杨晔
出处 《海军总医院学报》 2006年第3期160-163,共4页 Journal of Naval General Hospital of PLA
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参考文献22

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