电刺激迷走神经对严重烫伤大鼠的治疗作用

Therapeutic Effect of Electrical Stimulation of Efferent Vagus Nerve on Severely Scalded Rats

目的:观察电刺激迷走神经对严重烫伤大鼠平均动脉压(MAP)、心率、存活时间及存活率的影响。方法:取24只健康成年SD雄性大鼠(200-240 g),30%TBSAⅢ度烫伤,随机分为假伤组(Sham组)、烫伤组(Scald组)、迷走神经切断组(VGX组)、迷走神经电刺激组(STM组)。各组大鼠右颈总动脉置管后通过压力传导系统与心电监护仪相连,以连续监测MAP和心率变化,并记录生存状况。结果:STM组血压、心率下降趋势平缓,各时间点血压和心率明显高于Scald组和VGX组,生存时间延长,存活率高。结论:电刺激迷走神经对严重烫伤大鼠具有治疗作用。

Objective： To investigate the effect of electrical stimulation of efferent vagus on severely scalded rats, through observing mean arterial pressure（MAP）, heart rate（ HR）, survival time and survival rate. Methods： Twenty-four male Sprague-Dawley rats subjected to 30% TBSA Ⅲ degree scalded were employed as the model. The rats were randomly divided into four groups,including Sham group,Scald group,VGX group and stimulation （STM） group. The common carotid artery of the rats in every group were implanted into a blood pressure transducer for continuously recording of MAP and HR. Survival time and survival rate of rats were recorded at the same time. Results： Compared to those in Scald and VGX group, the MAP and HR of STM group were higher obviously, the decreasing of MAP and HR were milder, the survival time was longer, and the survival rate was higher. Conclusion： The direct electrical stimulation of the peripheral vagus nerve can significantly prevent the development of hypotension and step-down of HR in severely scalded rats,and increase survival time and survival rate,thus it might produce a potential therapeutic effect on severely scalded rats.