“头孢沙星”对小鼠的急性毒性试验

Acute Toxicity Test of New Animal Antibiotic Medicine "Toubaoshaxing" in Mice

用150只清洁级昆明系健康小鼠,进行“头孢沙星”原药1、0 g/L制剂口服及腹腔注射急性毒性试验。结果表明,其原药LD0在10 g/kg^15 g/kg之间,LD100大于15 g/kg;其10 g/L制剂LD50=527.38 mg/kg,95%可信限范围391.84 mg/kg^696.44 mg/kg。“头孢沙星”原药属于实际无毒,10 g/L制剂按2 mg/kg临床应用安全。

The acute toxicity tests of ＂Touhaoshaxing＂ and 10 g/L preparation were carried out in 150 mice. The results showed that＂TouBaoShaXing＂ maximal tolerance dose （LD0） varied from 10 g/kg to 15 g/kg, and absolute lethal dose （LD100）〉 15 g/kg. Median lethal dose （LD50）of 10 g/L preparation was 527.38 mg/kg. The 95% certainty factor varied from 391.84 mg/kg to 696.44 mg/kg. Such a conclusion can be obtained that＂Toubaoshaxing＂ is nontoxicity and 2 mg/kg dose of 10 g/L preparation is clinical safe.