CD40/CD40配体结合产生共刺激信号对干细胞及B细胞增殖分化的影响(英文)

Influence of co-stimulatory signal produced by CD40/CD40 ligand on the proliferation and differentiation of leukemic stem cells and B cells

目的:探讨CD40/CD40配体结合产生的共刺激信号对干细胞、B细胞增殖分化的影响及CD40配体抗白血病的作用。资料来源:检索Pubmed和Springer数据库1995-01/2005-12与CD40/CD40配体、白血病干细胞及白血病相关文献,检索词为“CD40,CD40L,Leukemia,Leukemicstemcell”,限定文献语种为英语。资料选择:对资料进行初审,选取实验包括实验组和对照组的文献,排除明显不随机实验和临床研究及重复性研究。资料提炼:共收集到30篇关于CD40/CD40配体结合产生的共刺激信号对干细胞、B细胞增殖分化的影响及CD40配体抗白血病作用的实验文章,23篇符合纳入标准,排除的7篇均为同一研究。资料综合:综合23个实验包括CD40/CD40配体对白细胞干细胞、B细胞增殖分化的影响,对白血病患者预后的影响及CD40配体对白血病患者的治疗作用,并对CD40/CD40配体对白细胞干细胞、B细胞及白血病患者的影响、作用进行分析。结论:CD40/CD40L结合所产生的共刺激信号可促进白血病干细胞和B细胞的增殖分化,与白血病的发生、发展和预后有密切关系。CD40/CD40L在免疫应答中起关键作用,广泛应用于白血病的免疫治疗。

OBJECTIVE： To investigated influence of co-stimulatory signal produced by CD40/CD40 ligand （CD40L） on proliferation and differentiation of leukemic stem cells and B cells as well as the role of CD40L anti-leukemia. DATA SOURCES： We searched Pubmed database and Springer database for the related literatures on CD40/40L, leukemic stem cell and leukemia published from January 1995 to December 2005, using the keyword ＂CD40, 40L, leukemic stem cell, leukemia＂ in English. STUDY SELECTION： We focused on published data that included the literatures of experimental groups and control groups, excluded obviously no random experiments, no random clinical studies and repeated researches. DATA EXTRACTION： We collected 30 experimental articles on influence of co-stimulatory signal produced by CD40/CD40L on proliferation and differentiation of leukemic stem cells and B cells as well as the role of CD40L anti-leukemia. Twenty-three articles that met inclusion criteria, excluded 7 articles were the same research ones. DATA SYNTHESIS： Twenty-three trials included influence of co-stimulatory signal produced by CD40/CD40L on proliferation and differentiation of leukemic stem cells, B cells and prognosis of leukemia, and the treatment of leukemic patients by CD40L. We analyzed the influence and role of co-stimulatory signal produced by CD40/CD40L on proliferation and differentiation of leukemic stem cells, B cells and leukemia. CONCLUSION： The evidence conformed that co-stimulatory signal produced by CD40/CD40L promoted proliferation and differentiation of leukemic stem cells , B cells, and it is important for the occurrence, progress and prognosis of leukemia. CD40/CD40L plays a crucial part in immune response, and proves wide application in the immune therapy of leukemia.