摘要
帕金森病患者存在中枢和外周血中免疫系统功能的改变。中枢的改变主要有小胶质细胞的激活,细胞因子、补体成分和凋亡相关蛋白水平的改变,抗多巴胺能神经元抗体和D2受体的抗体存在等。外周血中,T细胞亚群的比例发生变化,CD4+/CD8+比值降低,细胞因子的水平改变,氧化DNA损伤的发生,血清IgG对多巴胺能神经元的损伤,Fas/FasL的表达明显增高等。动物实验证实一些免疫治疗可有助于保护多巴胺能系统。
Alterations of immunological function in PD patients have been found both in CNS and in peripheral blood lymphocyte. Intracerebral changes include activation of microgliocyte, changes in the levels of cytokines,complements and apoptosis-related protein, the presence of neuron-specific antibodies and antibodies against D2 receptor.In peripheral blood ,the percentage of T lymphocyte subsets changes, ratio of CD4^＋/CD8^＋ is decreased, production of cytokines changes, oxidative damage of DNA occurs and expression of Fas/FasL increase. Animal experiments proved that some immunotherapy may protect dopaminergical system from inflammatory damage.
出处
《中国临床神经科学》
2006年第5期553-556,共4页
Chinese Journal of Clinical Neurosciences
关键词
帕金森病
免疫功能
外周血淋巴细胞
Parkinson＇s disease
immunologic function
peripheral blood lymphocyte
