1Arai M,Utsunomiya J ,Miki Y. Familial breast and ovarian cancers[J]. Int J Clin Oncol, 2004,9(4):270-282.
2Hall J M,Lee M K, Newman B, et al. Linkage of early-onset familial breast cancer to chromosome 17q21[J]. Science, 1990,250(4988): 1684-1689.
3Hakem R, de la Pompa J L, Sirard C, et al. The tumor suppressor gene Brcal is required for embryonic cellular proliferation in the mouse[J]. Cell, 1996,85(7):1009-1023.
4Scully R, Chen J, Ochs R L, et al. Association of BRCA1 with Rad51 in mitotic and meiotic cells[J].Cell, 1997,88(2) : 265--275.
5Wang Y, Cortez D, Yazdi P, et al. BASC, a super complex of BRCA1 associated proteins involved in the recognition and repair of aberrant DNA structures[J]. Genes Dev, 2000,14 (8) : 927-939.
6Wooster R, Neuhausen S L, Mangion J, et al. Localization of a breast cancer susceptibility gene, BRCA2, to chromosome13q12-13[J].Science, 1994,265( 5181 ) : 2088- 2090.
7Antoniou A, Pharoah P D, Narod S, et al. Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case ,series unselected for family history: acombined analysis of 22 studies[J].Am J Hum Genet, 2003, 72(5):1117-1130.
8Noruzinia M, Coupler I, Pujol P. Is BRCA1/BRCA2-related breast carcinogenesis estrogen dependent?[J].Cancer, 2005,104 (8):1567-1574.
9Armes J E, Trute L, White D, et al. Distinct molecular pathogeneses of early onset breast cancers in BRCA1 and BRCA2 mutation carriers: a population based study[J].Cancer Res, 1999,59(8),2011-2017.
10Xu X, Wagner K U, Larson D, et al. Conditional mutation of Brcal in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation[J]. Nat Genet,1999,22(1):37-43.
8Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2008[J]. CA Cancer J Clin, 2008, 58(2) : 71-96.
9Brinton L A, Sherman M E, Carreon J D, et al. Recent trends in breast cancer among younger women in the Uniled States[J]. J Natl Cancer Inst, 2008,100(22): 1643-1648.
10Han W, Kim S W, Park I A, et al. Young age: an independent risk factor for disease free survival in women with operable breast caneer[J]. BMC Cancer, 2004,4(82): 2360-2368.