我国乳腺癌热点问题研究的现状分析

Analysis of highlights of breast cancer current research in China

目的：通过对国内近年来有关乳腺癌文献的统计与分析，了解国内乳腺癌研究的热点及现状，供今后开展研究作参考。方法：在国内公开发行的期刊杂志中有代表性地选取与乳腺癌研究相关的54种杂志，选取发表时间在2003年5月～2005年4月的论著类文献，以乳腺肿瘤为主题词，乳腺癌为关键词，采用中国生物医学文献数据库（CBM）进行检索、分类、编号，采用SPSS12．0统计分析软件进行统计。结果：同期发表文献总数为42333篇，符合上述检索条件的乳腺癌相关文献共1156篇，占论文总数的2．73％。按照基础研究和临床研究分为两大类，基础研究文献415篇，占总篇数的35．90％；临床研究方面的文献741篇，占总篇数的64．10％。结论：乳腺癌的研究总体上比较活跃，其中临床研究数量较多，但仍缺乏高水平的多中心随机对照Ⅲ期临床实验。基础研究重复较多，样本数较小。

OBJECTIVE： To understand the Chinese breast cancer research highlights and present status for the reference of the future research. METHODS： Fifty-four representative journals related to breast cancer in China were chosen and analysed. With the CBMdisc database, breast neoplasms as subject words and breast cancer as key words, the papers （without review） from May, 2003 to Apr, 2005, were picked out, categorized and numbered, then analysed with SPSS 12.0 software. RESULTS： There were 42 333 papers at the period totally, and 1 156 of which fulfiled the terms. There were 415 papers （35.9%） in foundational research, and 741 （64. 1%） in clinical research. CONCLUSIONS： The breast cancer research goes actively generally. Clinical research is more advanced in number. However, there is still lack of high level multicenter randomized controlled Ⅲ phase clinical trials. There are many repeated works in foundational research, and the sample numbers are relatively small.