沙美特罗/丙酸氟替卡松干粉剂吸入治疗成人支气管哮喘60例疗效观察被引量：1

The curative effect of salmeterol and fluticasone propionate powdered inhalation on 60 cases of adult bronchial asthma

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摘要目的:探讨沙美特罗/丙酸氟替卡松干粉剂(商品名:舒利迭,葛兰素史克公司出品)吸入治疗支气管哮喘的疗效。方法:90例患者随机分为2组,治疗组采用沙美特罗/丙酸氟替卡松干粉剂50/250"g每日2次吸入,对照组采用丙酸氟替卡松气雾剂(商品名:辅舒酮,葛兰素史克公司出品)250"g每日2次吸入,治疗第4、8周两次评价患者哮喘症状和疗效。结果:在治疗第4、8周,治疗组哮喘症状和对照组相比明显减轻。结论:舒利迭为沙美特罗/丙酸氟替卡松混合吸入剂,是控制哮喘的一个良好选择。 Objective To study the curative effect of salmeterol and fluticasone propionate powder inhalation device （Trade name is Seretide, produced by GlaxoSmithKline Company） on adult bronchial asthma. Method 90 asthma patients are divided into two groups randomly. The treated group are given Seretide 50/250μg, inhaled twice daily, while the control group are given fluticasone propionate nebulization （Trade name is Flxiotide, produced by GlaxoSmithKline Company） 250μg, inhaled twice daily. Asthma symptom and curative effect are evaluated in the 4th and 8th weeks after treatment. Results Compared with the control group, asthma symptom during day and night in the treated group decreased obviously （P〈0.05） after 4 and 8 weeks＇ treatment. Conclusion Seretide is an admixture of powdered inhalant including salmeterol and fluticasone propionate, and it is an excellent choice for the control of adult asthma.

作者朱莉英龚正华

机构地区江苏省张家港市中医院呼吸内科

出处《吉林医学》 CAS 2006年第9期1041-1041,1043,共2页 Jilin Medical Journal

关键词沙美特罗丙酸氟替卡松支气管哮喘 Salmeterol Fluticasone propionate Bronchial asthma

分类号 R562.25 [医药卫生—呼吸系统]

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参考文献4

1蔡柏蔷.呼吸内科学[M].北京：中国协和医科大学出版社,2000.812.
2支气管哮喘防治指南[J].中华结核和呼吸杂志,1997,20(5):261-267. 被引量：2007
3徐喜媛,杨敬平,孙德俊.沙美特罗/丙酸氟替卡松联合应用治疗重度哮喘疗效观察[J].中国呼吸与危重监护杂志,2005,4(2):147-148. 被引量：6
4殷凯生.支气管哮喘诊治新进展[J].江苏省第十一次呼吸病学术会议论文汇编,2005:20.

二级参考文献8

1刘春涛.新指南,新起点[J].中国呼吸与危重监护杂志,2003,2(1):3-13. 被引量：31
2Jenkins C,Woolcock AJC, Saarelainen P, et al. Salmeterol/fluticasone propinate combination therapy 50/250 microg twice daily is more effective than budesonide 800 microg twice daily in treating moderate to severe asthma. Respir Med, 2000; 94: 715～723.
3Kips JC, O'Connor BJ, Inman MD, et al. A long-term study of the antiinflammatory effect of low-dose budesonide plus formoterol versus high-dose budesonide in asthma. Am J Respir Crit Care Med,2000; 161:996 ～ 1001.
4Green SA, Spasoff AP, Coleman RA, et al. Sustained activation of a G protein-couple receptor via 'anchored' agonist binding:molecular localization of the salmeterol exosite within the bata2-adrenergic receptor. J Biol Chem, 1996; 271: 24029 ～ 24035.
5Johnson M. The β-adrenoceptor. Am J Resp Care Med, 1998;158: S146 ～ S153.
6Mak JC, Nishikawa M, Barnes PJ. Glucocorticosteroids increase β2-adrenergic receptor transcription in human lung. Am J Physiol, 1995 ;268: L41 ～ L46.
7Baraniuk JN, Ali M, Brody D, et al. Glucocorticoids induce beta 2-adrenergic receptor function in human nasal mucosa. Am J Respir Crit Care Med, 1997; 155:704 ～ 710.
8Eickelberg O,Roth M,Lorx R,et al. Ligand-independent activation of the glucocorticoid receptor by β2-adrenergic receptor agonists in primary human lung fibroblasts and vascular smooth muscle cells.J Biol Mol Chem, 1999 ;274:1005～1010.