缺氧缺血性脑病新生儿神经元特异性烯醇化酶含量的变化被引量：3

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摘要目的探讨缺氧缺血性脑病(HIE)新生儿神经元特异性烯醇化酶(NSE)水平的变化,及其对缺氧缺血性脑损伤早期诊断、损伤程度判断和预后评估的临床意义。方法66例确诊为HIE的患儿,分别在出生后24h(急性期)内及日龄第7天(恢复期)采血样送实验室,检测NSE浓度,并与正常对照组(20例)进行比较。观察HIE病因以及脑损伤程度诸因素对血清NSE水平的影响。结果胎儿宫内窘迫组和出生窒息组急性期和恢复期NSE浓度均较正常对照组明显升高,差异有显著性(均P<0.05)。而宫内窘迫组和出生窒息组之间两次NSE浓度比较差异均无显著性。轻度和中、重度组急性期NSE浓度均较正常对照组明显升高,差异有显著性(P<0.05)。轻度组恢复期NSE浓度已接近正常,中、重度组仍高于正常对照组和轻度组,差异有显著性(P<0.05)。结论血清中NSE水平随缺氧缺血性脑损伤严重程度而升高,可作为判断新生儿脑损伤程度的可靠指标。胎儿宫内窘迫所致缺氧缺血性脑损伤与出生后窒息相近,在诊断和治疗上应予以同等重视。

作者薛新宏庞保东王大力李瑛瑜王丽娟常莉莎赵晓晶

机构地区华北煤炭医学院附属医院神经内科二病区河北省唐山市妇幼保健院

出处《中国综合临床》北大核心 2006年第11期1042-1044,共3页 Clinical Medicine of China

关键词缺氧缺血性脑病神经元特异性烯醇化酶新生儿

分类号 R722.12 [医药卫生—儿科]

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1Per Johnsson,Sten Blomquist,Carsten Luhrs,et al.Neuron-specific enolase increases in plasma during and immediately after extracorporeal circulation[J].Ann Thorac surg,2000,69 (3):750-754.
2Jones NM,Bergeron M.Hypoxic preconditioning induced changes in HIF-1 target genes in neonatal rat brain[J].J-Cereb Blood Flow Metab,2001,21(9):1 105-1 114.
3Wimmer Greinecker G,Matheis G,Brieden M,et al.Neuropsychological changes after cardiopulmonary bypass for coronary artery bypass grafting[J].Thorac Cardiovasc Surg,1998,46(4):207-212.
4Elimian A,Figueroa R,Verma U,et al.Amniotic fluid neuron specific enolase:a role in predicting neonatal neurologic injury[J].Obstetrics And Gynecology,1998,92 (4pt1):546-550.
5Farooqui AA,Horrocrs LA.Excitatory amino acid receptors,neural membrane phospholipids metabolism and neurological disorders[J].Brain Res Rev,1991,16(2):171-191.
6Monyer H,Sprengel R,Schoepfer R,et al.Heteromeric NMDA receptors:molecular and functional distinction of subtypes[J].Scrence,1992,256 (5 060):1 217.
7Currie SN,Wang XF,Daw NW.NMDA receptors in layers Ⅱ and Ⅲ of rat cerebral cortex[J].Brain Res,1994,662(1-2):103-108.
8Strijbos PJLM,Relton JK,Rothwell NJ.Corticotrophin releasing factor antagonist inhibits neuronal damage induced by focal cerebral ischemia or activation of NMDA receptors in the rat brain[J].Brain Res,1994,656(2):405-408.
9Koenig H,Goldstone AD,Lu CY,et al.Brain polyamines are controlled by NMDA recptors during ischemia and recirculation[J].Stroke,1990,21 (11 suppl):98-102.